Author of

• 20192

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  P3.13 - Radiology/Staging/Screening (ID 729)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Radiology/Staging/Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24184

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    P3.13-032 - The Impact of Tobacco Exposure on Lung Nodules and Emphysema in a Pilot Silesian Study of Early Lung Cancer with LDCT (ID 10189)

    09:30 - 09:30  |  Author(s): Ewa Wachu?a
    • Abstract

    Background:
    Pulmonary emphysema is known to be related to an increased incidence of lung cancer. The risk factors of emphysema and lung cancer are smoking history and envirolmental pollution. Low-dose chest CT is useful method for imaging both: emphysema and solitary pulmonary nodules (SPN).
    
    Method:
    We have enrolled a total of 602 healthy volunteers to the Pilot Silesian Study of Early Lung Cancer Detection with LDCT. Retrospectively we analyzed the baseline round of LDCT scans. One person was excluded due to presence of lung cancer symptoms. Gradual accrual period lasted for two years, from 2010 to 2012. The positive result was defined as a presence of solid or part-solid nodule equal to or larger than 5 mm or non-solid equal to or larger than 8 mm. Participants were stratified by exposure to tobacco smoke into five groups: A) current smokers with a history of at least 40 years of smoking - chronic smokers; B) current smokers with a history of smoking at least 40 cigarettes per day - intensive smokers; C) former smokers who quit smoking fewer than 5 years ago; D) former smokers who quit smoking at least 10 years ago; E) exposed to a second-hand tobacco smoke. With the statistical methods we analized corelations between this five groups depending on tobacco exposure and demographic features.
    
    Result:
    We identified 1016 lung nodules in 265 individuals. A total of 410 nodules coexisted with emphysema in 99 individuals. In group with emphysema we diagnosed 3 early lung cancers, unlike to the group without emphysema, in which we diagnosed 4 cancers (HR=0.7 95% CI 0.16-1.02). Subsolid morphology and diameter of a nodule larger than 5 mm were associated with higher risk of malignancy. Emphysema and lung nodules were more often found in the group of chronic smokers (>40 years) - 8.1% (A), in comparison to the group of intensive smokers – 0.8% (B). There were no statistically significant differences in both subcohorts of former smokers (for group C and D, 2.1% and 2.3%, respectively).
    
    Conclusion:
    In the subgroup of chronic smokers emphysema and lung nodules were more likely to occur. Additional risk factors for the presence of lung nodules and emphysema were: age (above 65 years) and occupational exposure (especially coal miners and welders).