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Inbar Finkel
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P2.07 - Immunology and Immunotherapy (ID 708)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Immunology and Immunotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.07-048 - Immunotherapy vs. Targeted Therapy - Who Wins? A Case Series (ID 10234)
09:30 - 09:30 | Presenting Author(s): Inbar Finkel
- Abstract
Background:
Data are mounting regarding rare mutations such as MET (exon 14 skipping mutation and MET amplification), ROS1 translocation and rare EGFR mutations and response to targeted therapy, simultaneously data are increasing concerning treatment of Non-Small Cell Lung Carcinoma (NSCLC) patients with immune check point inhibitors. As yet, the role of immunotherapy in patients with rare genomic alterations has not been determined. We describe a case series of patients who can benefit from both therapies and summarizes their response for each treatment.
Method:
We present a retrospective case series of four patients with NSCLC and genomic alterations, diagnosed and treated from November 2015 to June 2017 in a single tertiary center with targeted therapy and immunotherapy. Hybrid capture-based next generation sequencing was performed.
Result:
Two males and two females (mean age 58) were included. Three of them were diagnosed with Adenocarcinoma and the remaining one was diagnosed with squamous cell carcinoma. Each patient was diagnosed with a specific gene alteration (C-met exon 14 skipping mutation, EGFR Q861L, MET amplification and ROS1 translocation). Patients underwent targeted therapy as well as immunotherapy. Two patients had PD-L1 staining >50%. One patient demonstrated an early and durable complete response with immune check point inhibitors, one patient had progressed on immunotherapy quickly but respond well to targeted therapy, two patients responded as expected to targeted therapy and got immune check point inhibitors as a second line and still being treated with good response.
Conclusion:
The role of immunotherapy for patients with uncommon EGFR mutations, ROS1 and C-MET who express PD-L1 is still unclear. Further studies in this unique population are needed.
