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Jiancheng Li
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P2.01 - Advanced NSCLC (ID 618)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:00 - 16:00, Exhibit Hall (Hall B + C)
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P2.01-073 - Prognostic Factors Analysis of Non-Small Cell Lung Cancer with Brain Metastases (ID 10155)
09:00 - 09:00 | Presenting Author(s): Jiancheng Li
- Abstract
Background:
There is a high incidence of brain metastases in non-small cell lung cancer， result in treatment failure. The usual outcome of untreated patients is very poor. How to improve living quality and extend the median survival is a hot item for clinical studies. Therefore, this study attempted to analyze the prognostic factors of the non-small cell lung cancer with brain metastases.
Method:
145 patients who were diagnosed for brain metastasis from Non-small cell lung primary cancer by MRI at the Cancer Hospital affiliated to Fujian Medical University from January 2010 to December 2013 were retrospectively reviewed．A number of potential influencing factors which might affect prognosis were evaluated，including age，gender, pathological type，Karnofsky performance score（KPS），tumor and lymph node staging, internal from diagnosis of lung cancer to the development of BM，symptoms at BM diagnosis，number of BM，region of BM，maximum diameter of BM，peritumoral brain edema，radiation boost following WBRT and the treatments．Survival time was recorded from BM diagnosed to die or final follow-up．Survival rate was calculated by Kaplan-Meier method．Log-rank method was adopted to compare the difference of each inferior group in survival rate．The multi-variate analysis about survival was performed with Cox’S regression proportional model．Statistical significance was defined as P<0.05．
Result:
There were 145 patients in the research，median survival time（MST） from BM diagnosed was 13.0 months，6-month，1-year and 2-year survival rates were82.8%， 52.4％and 25.8％,respectively。The univariate analysis showed KPS，the presence of extracranial metastases, symptoms at BM diagnosis , both side of the brain metastases , meningeal metastases and maximum diameter of BM had tendency to statistical differences(P value are 0.009、0.004、0.019、0.044、0.023、0.044,respectively). The multivariate analysis indicated that the presence of extracranial metastases, symptoms at BM diagnosis and meningeal metastases were closely related to the prognosis.
Conclusion:
Based on the results of our study, we confirmed that meningeal metastases, no extracranial metastasis and no Symptoms at BM diagnosis are independent prognostic factors in NSCLC with brain metastases.
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P3.12 - Pulmonology/Endoscopy (ID 728)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Pulmonology/Endoscopy
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.12-004 - Maidong on the Prevention and Treatment of Radiation Pneumonitis in Mice C57BL/6 (ID 10146)
09:30 - 09:30 | Presenting Author(s): Jiancheng Li
- Abstract
Background:
Radiation pneumonia is the most serious complications after radiotherapy of thoracic tumor. We use the Maidong extract as essential prescription, to assess its prevention and control effect of radiation pneumonia, and to explore its possible mechanism.
Method:
60 C57BL/6 mice were divided into:(1) blank control group, (2)merely irradiated group, (3)Chinese medicine (Maidong) group, and (4)western medicine (dexamethasone combine cefalexin)group, each group of 15 mice. Maidong extract was given 1 times per day to the mice of Chinese medicine group, dexamethasone and cefalexin were given 1 times per day to the mice of western medicine group by intragastric administration from 4 days prior to the irradiation day, last for 2 weeks; merely irradiated group and blank control group were given physiological saline instead. In addition to the blank control group, other groups were given chest a 6MV-X-ray single-wide irradiation of 18Gy.Each group randomly sacrificed 5 mice at 24 hours, 4 weeks, 12 weeks after irradiation. Took the blood, left lungs into homogenate and fixed right lungs in formaldehyde solution for research.
Result:
1, Compared to the merely irradiated group, the level of plasma IL-6(P<0.01), TNF-α(P<0.05)and TGF-β1(P<0.01), hydroxyproline(P<0.05) and MDA (P<0.01)content of the lung tissue in the Chinese medicine group mice were significantly reduced, SOD activity was significantly enhanced (P<0.01),and the expression of MMP-2(P<0.01) and TIMP-2(P<0.05) proteins were significantly reduced. 2, Compared to the western medicine group, the level of plasma IL-6, hydroxyproline content and SOD activity of the lung tissue, the expression of TIMP-2 protein didn’t show significant difference(p>0.05); because of the increase of the level of plasma TNF-α and TGF-β1(P<0.05), MDA (P<0.01)content of the lung tissue in western medicine group mice,the Chinese medicine group were significantly different at 12week; the expression of MMP-2(P<0.05) protein the Chinese medicine group were significantly higher than western medicine group at 4week, but didn’t show significant difference at 12week.
Conclusion:
Maidong has certain effect on the prevention and control of radiation pneumonia, the preventive effect may be achieved through the many kinds of approaches: Maidong is relatively more enduring than dexamethasone combine cefalexin, and Maidong had less side effects.
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P3.14 - Radiotherapy (ID 730)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.14-016 - Research About Different Administration Mode of Endostar for Combining with Concurrent Chemoradiotherapy in Local Advanced NSCLC (ID 10158)
09:30 - 09:30 | Presenting Author(s): Jiancheng Li
- Abstract
Background:
Radiotherapy is carried out five days in a week. Endostar is a target drug, its adminstration is d1-14 in three weeks. We changed endostar adminstration mode as the same of radiotherpy, five days in a week. Now we evaluate the efficacy and safety of different administration dose of endostar combined with concurrent chemoradiotherapy in ad vanced non-small cell lung cancer(NSCLC).
Method:
From September 2010 to December 2015，40 patients with local advanced NSCLC were recruited. All the patients received radiotherapy with 60Gy and two circles chemotherapy with docetaxel 75mg/m[2] d1 and cisplatin 75mg/m[2] d1～3，combined with two different administration dose of endostar(75mg/m[2] d1-14 in three weeks for two cycles and 75mg/m[2] d1-5 in one week for six cycles concurrent with radiotherapy. Tumor response were evaluated with RECIST1.1 criteria. Acute toxicities were evaluated with NCICTC3.0 and RTOG criteria.
Result:
In group one，2 patients achieved complete response，10 partial response，3 stable disease，5 progressive disease. Overall response rate was 60%. The 1-year progressive-free-survive rate was 40%. The 1-，2-year survival rates were 70% and 25%. The median overall survive is 19.9 month. In group two，overall response rate was 75%. The 1-year progressive-free-survive rate was 50%. The 1-，2-year survival rates were 80% and 45%. The median overall survive is 22.7 month. In group 2 there had a good survival and patient compliance, but there were no significant difference between two groups (P>0.05).
Conclusion:
Endostar combined with concurrent chemoradiotherapy is useful and well-tolerance. Administration mode of endostar combining with chemoradiotherapy, which is five day in a week for six weeks, had a better result and patient compliance.
