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Hengrui Liang



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    MA 12 - Circumventing EGFR Resistance (ID 665)

    • Event: WCLC 2017
    • Type: Mini Oral
    • Track: Advanced NSCLC
    • Presentations: 1
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      MA 12.11 - The Alteration of T790M Prevalence Between 19 Deletions and L858R in NSCLC After EGFR-TKIs Therapy, a Meta-Analysis (ID 10077)

      12:10 - 12:15  |  Presenting Author(s): Hengrui Liang

      • Abstract
      • Presentation
      • Slides

      Background:
      Pre-treatment EGFR T790M mutation is more likely to coexist with L858R mutation than with exon 19 deletions (19del) in NSCLC. However, EGFR-TKIs might alter this status. We sought to compare the prevalence of T790M upon acquired resistance to EGFR-TKIs between 19del and L858R by assembling all existed data.

      Method:
      Electronic databases were comprehensively searched for eligible studies. The primary endpoint was the odds ratio (OR) of T790M mutation in NSCLC co-existing with L858R mutation and 19del upon resistance to first-generation EGFR-TKIs. A random effects model was used. Stratified analysis was performed based on study type (retrospective and prospective), race (Asians and Caucasians) and sample type (tissue and plasma).

      Result:
      A total of 25 studies involving 1,770 patients were included. The overall T790M existent rate was 45.25%. Post-resistance T790M was more frequent in 19del than in L858R mutated patients (53% vs. 36%; OR 1.87; p=0.00). All outcomes of subgroup and overall analyses were similar. In contrast, we re-analyzed the previous meta-analysis, finding that the pooled rate of pretreatment T790M was 14% and 22% in 19del and L858R respectively (OR 0.59; p<0.01). The increase of T790M rate was 2.79-fold in 19del and only 0.63-fold in L858R in the course of EGFR-TKIs therapy.

      Conclusion:
      Opposite to the situation of de novo T790M, it was observed that T790M was more frequent in exon 19del than in L858R among EGFR-TKI resistant acquired patients. The difference in T790M alteration between 19del and L858R encourages development of specific resistance mechanism detection or treatment strategies.

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    P1.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 692)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
    • Presentations: 1
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      P1.06-019 - The Association Between HPV Presence and EGFR Mutations in Asian Patients with NSCLC: A Meta-Analysis (ID 10108)

      09:30 - 09:30  |  Presenting Author(s): Hengrui Liang

      • Abstract
      • Slides

      Background:
      The etiology of non-smoking NSCLC remains largely unknown. It has been widely proved that human papillomavirus (HPV) participate in the development of various cancers unrelated to smoking. Epidermal growth factor receptor (EGFR) mutation patients represent a large part of non-smokers with NSCLC. We performed this meta-analysis to evaluate whether HPV infection in NSCLC tissue is associated with EGFR mutation compared with HPV negative controls.

      Method:
      MEDLINE, EMBASE, PubMed and Web of Science were searched through June 2017, using the search terms “lung cancer”, “human papillomavirus”, “HPV”, “epidermal growth factor receptor”, “EGFR” and their combinations. We included studies in which HPV detection was based on PCR methods. Association was tested using odds ratio (OR) with 95% confidence intervals (95%CI). Heterogeneity was assessed using Q and I[2] statistic.

      Result:
      Finally, three studies with a total of 288 patients from Asian countries were identified as eligible publications. The presence of EGFR mutation was significantly related to HPV DNA compared with HPV negative controls (57% vs. 27%，OR 3.91, 95% CI 1.85 to 5.50; p<0.001), with no statistical heterogeneity among studies (I[2]=0; p=0.525).

      Conclusion:
      Our results suggest that HPV may contribute in part to EGFR mutations in non-small cell lung cancer, at least in Asian population.

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