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Nil Molinas Mandel



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    P3.02 - Biology/Pathology (ID 620)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Biology/Pathology
    • Presentations: 1
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      P3.02-097e - Prognostic Importance of Tumor Spread Through Air Spaces in Lymph Node Negative Operated Adenocarcinoma Lung Cancers (ID 9617)

      09:30 - 09:30  |  Author(s): Nil Molinas Mandel

      • Abstract

      Background:
      STAS (Spread through air spaces) defined as spreading of tumor cells to the adjacent pulmonary paranchyme by using air spaces, is a new invasion indicator adenocarcinoma lung cancers. In our study we aim to investigate relation between survey and lymph node existence as considering STAS

      Method:
      We evaluate the adenocarcinoma lung cancer patients had lobectomised or pneumonectomised in American Hospital and Koc University Hospital between 2000 -2016. Locally advanced cases and patients some may be prognostic positive factors other than STAS didn't considered. According to these criteria totally 171 patients counted in our study. STAS existence statistically analyzed in terms of lymph node metastasis and survey relation. In survey analysis we examined the data of patients had operrated before November 2011, owing to significance of follow up time

      Result:
      103 of 171 patients were men (60,2%) and 68 of them were women (39,8%). Characteristic specialities and dermographic datas of them has demonstrated in 1st chart. Lymph node invasion (N1-N2) and alveolar spread togetherness was in statistically significant ratio comparing with the cases who hasn't alveolar spread (38.33% vs 24.32% p:0.05) When in last 5 years operated patients were excluded from study, 66 left. And 42 of them were men (63.6%) , 24 of them were women (36.4%) Mean age were 61.82/+-10.26 (36-84). Mean follow up time has detected as 58.98 months. Average survey was 71.47 months in patients has alveolar spread and 79.8 months at patients who hasn't. There weren't statistically significant difference between these two groups (p=0.66) When we analyzed survey of lymph node negative cases, we detected patients with alveolar spread had statistically worse survey (62.53 months versus 90.63 months , p=0.05)

      Conclusion:
      Instead of sublober rejections in lymph node negative patients with alveolar spread, low survey and high recurrence probability must be considered while to approach lober rejections. And in only STAS existence even if lymph nodes are negative, adjuvant therapy is recommended.

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    P3.13 - Radiology/Staging/Screening (ID 729)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Radiology/Staging/Screening
    • Presentations: 1
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      P3.13-024 - Is Alveolar Spread May Be Predictive with PET CT Scanning? (ID 9921)

      09:30 - 09:30  |  Presenting Author(s): Nil Molinas Mandel

      • Abstract
      • Slides

      Background:
      In this study we aim to investigate predictivity of alveolar spread in primary lung cancer by using preoperatively scanning methods

      Method:
      In order to re-evaluate alveolar spread, pathology preparations of 45 patients had operated for primary lung cancer diagnosis and scanned preoperatively with PET CT all in our hospital which interpreted by same nuclear medicine specialists implicated in this study. As using the patients pet CT findings, CTV (computerized tomography volume), MTV (metabolic tumor volume), TLG(total lesion glycolysis), SUDmax, SUDort values and their relation with alveolar spread analyzed

      Result:
      Preoperatively PET-CT scanned all in our hospital 45 patients has included and cause of couldn't reach their pathological preparations, 6 of them exluded from the study. 21 of 39 patients were men (53.8%) , 18 of them were women (46.2%) and mean age was 66.67/+-7.88 (42-80). We didn't detect any relation between CTV, MTV, TLG, SUDmax, SUDort values and alveolar spread (p>0.05). However when the CTV/ MTV ratio analyzed, alveolar spread was statistically more common in the group of patients had ratio lower than 1. (62.9% versus 0% , p:0.01)

      Conclusion:
      High local recurrence risk in sublober rejected patients with alveolar spread has indicated in various studies. Regarding this matter, we recommend re-evaluation of the patients for sublober rejections whose CTV/MTV ratio is lower than 1.

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