Virtual Library
Start Your Search
Kazutoshi Hamanaka
Author of
-
+
P3.13 - Radiology/Staging/Screening (ID 729)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiology/Staging/Screening
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
-
+
P3.13-023 - Clinicopathological Impacts of the Small Ground-Glass Opacity Surrounding the Solid Type Lung Adenocarcinoma (ID 9825)
09:30 - 09:30 | Presenting Author(s): Kazutoshi Hamanaka
- Abstract
Background:
There were many reports and evidences for part-solid nodules with ground-glass opacity (GGO) in small-sized lung adenocarcinoma, and the component of GGO has been known to be a factor of malignant potency of the tumor, although the relation between radiological appearance of >2cm or >3cm lung adenocarcinoma and clinicopathological features were less noted.
Method:
A total of 136 patients with >2cm lung adenocarcinoma with >0.75 of consolidation to tumor ratio (C/T ratio) who underwent lung resection at Shinshu University Hospital from February 2003 through December 2010 were assessed. Among these patients, 83 with pure solid appearance in preoperative thin section computed tomography (C/T ratio = 1.0) were placed into Solid group, and 53 with small GGO surrounding the solid type tumor (0.75 < C/T ratio < 1.0) were placed into Subsolid group in this study. We retrospectively analyzed the clinicopathological features and prognosis after surgery in each groups.
Result:
The maximum standardized uptake value (SUVmax) of the tumor in preoperative radiological assessment using [18F] fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were significantly higher (p=0.0048) in Solid group (7.65±4.36) than Subsolid group (4.82±3.32). The presence rate of vascular invasion (Ly or V) was 54.2% in solid group and 39.6% in Subsolid group. The numbers of node positive patients were 19 with N1, 27 with N2 in solid group, and 8 with N1, 7 with N2 in Subsolid group respectively, and the rate was significantly higher in Solid group (p=0.0019). The prognostic analysis of pathological stage 1 patients (29 patients in Solid group and 37 in Subsolid group) revealed that the overall survival and recurrence-free survival was significantly poorer (p=0.044 and p=0.019 respectively) in Solid group than in Subsolid group.
Conclusion:
The small GGO surrounding the solid type adenocarcinoma as C/T ratio >0.75 indicated lower malignant potency and better prognosis than pure solid tumor without GGO component. Even small GGO component was a clinical factor of favorable oncologic outcomes, it may contribute to regarding the decision making for surgical strategy in preoperative assessment.
