Author of

• 20174

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  P2.10 - Nursing/Palliative Care/Ethics (ID 711)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Nursing/Palliative Care/Ethics
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23459

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    P2.10-005 - Overall Survival of Lung Cancer Patients with Brain Metastases in a Developing Country (ID 9611)

    09:30 - 09:30  |  Presenting Author(s): Tomi Kovacevic
    • Abstract

    Background:
    Brain metastases (BM) are common in due course of lung cancer (LC). The clinical presentation of BM can be very distressing for family/caregivers and urges for immediate treatment. Despite the early diagnosis and multimodality treatment of BM, prognosis remains poor. Considering the fact that treatment options in developing countries are limited (WBRT, surgery and SBRT) individual approach and specific prognostic assessment is highly important for further disease management. Aim of this study was to gather information and make approximation of overall survival (OS) of LC patients with BM.
    
    Method:
    This observational trial was conducted at the Institute for Pulmonary Diseases of Vojvodina, Serbia in the period from March 2010 to April 2015 taking into account all newly diagnosed LC patients. All data were harvested from the hospital based data capture system. The survival estimations were calculated regardless of the therapeutic interventions applied. Median OS was determined via Kaplan-Meier curves for all subgroups of LC patients with BM.
    
    Result:
    BM were diagnosed in 336 (5.1%) out of 6.624 LC patients in this 5 year period. Out of them, 182 patients were eligible for evaluation in this trial, the rest were excluded due to missing data. Majority of patients were male 68.1% (124), older than 60 years 50.0% (91), smokers 73.6% (134) with ECOG PS 1 76.4% (139). Most frequent LC type was adenocarcinoma 59.3% (108) followed by small-cell, squamous cell, and other types; 19.2% (35), 13.2% (24) and 8.2% respectively (13). One BM was present in 63.0% (63), 2-3 BM in 52.0% (52) and more than 3 in 34.6% (63) of patients. Extra cranial metastases (ECM) were present in 60.4% (110) of patients Median OS of all patients with BM regardless the histology was 8.5 (95%CI: 7.8-12.2) months. Median OS of patients with NSCLC, SCLC and other tumour types was 8.5 months (95%CI: 6.0-10.9), 10.0 months (95%CI: 7.8-12.2), and 5.5 months (95%CI: 0.1-11.0) respectively. Lowest median survival period was observed in patients with ECOG PS >3; 3.60 (95%CI: 0.2-7.0) months.
    
    Conclusion:
    The survival results of this trial show consistency with historical survival times. These results may suggest that survival outcomes for LC patients with BM are independent of applied therapy. Approximate survival prognosis taking into consideration individual (age and ECOG) and objective (tumour type, number of BM and presence of ECM) patient characteristics is highly important for further disease management in order to decrease patients burden and increase cooperation with family/caregivers.