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Chu Leuk Lau



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    P3.13 - Radiology/Staging/Screening (ID 729)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Radiology/Staging/Screening
    • Presentations: 1
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      P3.13-020 - A Pilot Study of the Autoantibodies to Tumor Antigens in Lung Cancer Using the EarlyCDT-Lung Test in Hong Kong (ID 9585)

      09:30 - 09:30  |  Presenting Author(s): Chu Leuk Lau

      • Abstract

      Background:
      The EarlyCDT-Lung test detects autoantibodies to abnormal cell surface proteins in lung cancer patients. It has been studied in UK[1] and USA[2] in diagnosing lung cancer patients and has a sensitivity of up to 47%, specificity up to 90% and positive predictive value of 16%. It is a potential diagnostic test and when combines with radiological (Computed Tomography) test, the positive predictive value can be enhanced up to 72%[3]. We want to study the performance of the test in a predominantly Asian ethnic city. 1. Caroline J. Chapman
 et al. EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays. Tumor Biol. 2012; 33:1319–1326 2. JR Jett et al. Audit of the autoantibody test, EarlyCDT®-Lung, in 1600 patients: An evaluation of its performance in routine clinical practice. Lung Cancer 2014; 83:51–55 . 3. P Massion et al. Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer Journal of Thoracic Oncology 2017; 12:578-584

      Method:
      Patients who had been referred to our clinic for follow up for lung nodules from March 1st to May 30th, 2017 were included. EarlyCDT-Lung test was performed for those with size greater than 0.8cm or size less than 0.8cm with smoking pack-year more than 30 years. EarlyCDT-Lung test sensitivity and specificity were evaluated. Confirmed lung cancer patients were retrospectively compared with non-lung-cancer patients.

      Result:
      10 patients (Chinese: Caucasian=9:1) were included during the study period (Mean age=51.5; male gender=9 (90%); Smoker=2 (20%). 5 patients were diagnosed lung cancer (Mean tumor size=2.9cm; 1 with Stage IA; 1 with stage IB; 1 with stage IIIA, 2 with stage IV; with adenocarcinoma 5/5, EGFR+ve 2/5, ALK+ve 1/5. Mean age=54.8; male gender=4 (80%); Smoker=0 (0%). 5 patients were diagnosed non-lung-cancer (Mean tumor size=0.8cm. Mean age=48.2; male gender=5 (100%); Smoker=2 (40%). EarlyCDT-Lung test was positive in 1/5 lung cancer patients, while 0/5 in non-lung-cancer patients, giving rise sensitivity 20% (1/5), while specificity 100% (5/5).

      Conclusion:
      This pilot study gives the initial experience of EarlyCDT-Lung test for Asian with high specificity in limited number of subjects. A larger study is warrant for a more accurate result.