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Yasuhiko Ohshio
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P1.02 - Biology/Pathology (ID 614)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.02-030 - The Effect of Chronic Obstructive Pulmonary Disease on the Tumor Stroma in Non-Small Cell Lung Cancer (ID 9215)
09:30 - 09:30 | Presenting Author(s): Yasuhiko Ohshio
- Abstract
Background:
Inflammatory cytokines, including tumor necrosis factor-α (TNFα), interleukin(IL)-6, IL-8, and IL-18 in the blood are elevated in patients with chronic obstructive pulmonary disease (COPD), but the influence of COPD on the differentiation and function of cancer-associated fibroblasts (CAFs), which are the dominant stromal component in the tumor microenvironment, remains to be elucidated in non-small cell lung cancer (NSCLC) patients. The purpose of this study is to examined the relationship between degree of COPD and CAFs in NSCLC patients who had undergone the lung surgery.
Method:
The expression of αSMA in tumor tissue was analyzed by immunohistochemistry for 45 cases with COPD and 8 cases without COPD who had undergone lung cancer surgery between 2014 and 2015 to evaluate the frequency of CAFs. We evaluated the correlations between low attenuation area (LAA), Brinkman index (BI), FEV1/FVC, GOLD COPD Stages and frequency of CAFs in tumor tissue.
Result:
Univariate analysis showed a strong correlation between the frequency of CAFs and LAA (P＜0.001), BI (P＜0.001), FEV1/FVC (P＜0.001) except for GOLD COPD Stages (P=0.208). Multivariate analysis showed that LAA was significant predictors of frequency of CAFs in tumor tissue.
Conclusion:
Parameters obtained from the pulmonary function test and smoking index are often affected by the skill and memory of the patients. It was suggested that the LAA which objectively quantified the degree of emphysematous change was more related by the frequency of CAFs in tumor microenvironment.
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P3.16 - Surgery (ID 732)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.16-048 - The Role of Pulmonary Resection in Stage IVa Non-Small Cell Carcinoma Patients (ID 9907)
09:30 - 09:30 | Author(s): Yasuhiko Ohshio
- Abstract
Background:
In non-small cell lung cancer (NSCLC), pulmonary resection for stage IV patients was not recommended in standard therapy. However, various new treatments for advanced or recurrence NSCLC patients such as molecular-targeted therapy for driver oncogenes or immune checkpoint therapy have improved the survival of those patients in these days. Therefore, we need to review the role of surgery for advanced NSCLC patients again.
Method:
Clinical records of 334 patient diagnosed stage IV in Shiga University of Medical Science between 2006 and 2015 were reviewed and clinicopatholocgial features and overall survival were analyzed retrospectively.
Result:
32 patients underwent surgery in this period, and the patients included 25 men and 7 women, with median age of 70.0 years (52-82 years). There were 22 adenocarcinomas, 8 squamous cell carcinomas and 2 other histological subtypes. Surgery included 19 pulmonary resections, 3 spinal fixation surgery, 7 intracranial surgery and 3 other surgery. Median overall survival following surgery or non-surgery was 15.8 month and 9.9 months, respectively (P=0.002). Moreover, in 19 cases of pulmonary resection, there were 7 patients with pleural disseminations (IVa) and 12 patients with distant metastases (IVb). In case with disseminations (IVa), median overall survival was also significantly longer in patients with pulmonary resection than in those of non-operative 31 patients in the same period (42.2 months vs 8.3 months, P=0.038).
Conclusion:
Although further study in larger sets of patients would be warranted, surgery should not be excluded from treatment modality for stage IV patients, especially IVa cases if we could selected appropriately.
