Author of

• 20177

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  P2.13 - Radiology/Staging/Screening (ID 714)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Radiology/Staging/Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23473

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    P2.13-004 - Role of Low-Dose Chest Computerized Tomography in Lung Cancer Screening among Never-Smokers (ID 8977)

    09:30 - 09:30  |  Presenting Author(s): Hye-Rin Kang
    • Abstract

    Background:
    The incidence of lung cancer among never-smokers has been increasing rapidly. The US National Lung Screening Trial study showed that screening using low-dose chest computerized tomography (LDCT) effectively reduced lung cancer mortality among heavy-smokers. However, its effectiveness in never-smokers has not been studied. Therefore, this study investigated the role of LDCT in lung cancer screening among never-smokers.
    
    Method:
    In this single-center, retrospective, cohort study, we identified 4,054 (13.5%) non-smokers (age range: 40-75 years) among 30,080 patients who underwent LDCT for lung cancer screening at Seoul National University Bundang Hospital Health Promotion Center, between May 2003 and June 2016. We analyzed patients with abnormal LDCT findings and cancer rates. Abnormal LDCT findings, such as nodules, were classified according to the Lung-RADS criteria and the final pathologic outcomes were further analyzed. If multiple nodules were found, we selected one dominant nodule.
    
    Result:
    Among the 4,054 never-smokers, 2,519 (62.1%) were women. Among the 846 patients (20.8%) with lung nodules, 636, 112, 56, 34, and 8 had nodules categorized as 2, 3, 4A, 4B, and 4X, respectively, according to the Lung-RADS criteria. Among these, 315 (37.2%), 95 (11.2%), and 436 (51.5%) nodules were solid, part-solid, and non-solid, respectively. Moreover, 448 (52.5%) patients underwent further diagnostic work-up, including follow-up CT or diagnostic procedures. Finally, 38 (0.9%) patients were pathologically diagnosed as lung cancer. Among these patients, 34 (89.5%) were in stage I, and 33 (86.8%) had adenocarcinoma. No cancer-related death occurred, and the diagnostic work-up did not cause significant morbidity.
    
    Conclusion:
    In the never-smoker population, LDCT screening helped detect a significant number of lung cancers. Most of these lung cancers were detected at a very early stage.