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Shigeki Suzuki
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P1.05 - Early Stage NSCLC (ID 691)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.05-002 - Characteristics and Prognosis of Ground Glass Opacity Predominant Primary Lung Cancer Larger Than 3.0 Cm on Thin-Section Computed Tomography (ID 7396)
09:30 - 09:30 | Presenting Author(s): Shigeki Suzuki
- Abstract
Background:
The solid component size of lung cancer showing ground glass opacity (GGO) on thin-section computed tomography (TSCT) has been regarded as a more important preoperative prognostic indicator than the whole tumor size. Moreover, previous study revealed that radiological early lung adenocarcinoma which has an excellent prognosis could be defined as an adenocarcinoma 3.0 cm or less with consolidation to tumor ratio (CTR) of 0.5 or less on TSCT. However, the characteristics and the prognosis of lung cancer larger than 3.0 cm showing GGO remain unclear.
Method:
From January 2002 through June 2012, we retrospectively reviewed 3,735 consecutive patients with primary lung cancer, which underwent complete resection at our institution. We extracted 686 (18.4%) patients with lung cancer larger than 3.0 cm in diameter and evaluated their preoperative TSCT findings. In total, 160 (4.3%) lung cancers larger than 3.0 cm showing GGO were eligible for this analysis. We divided the 160 lesions into three types based on CTR; type A: 0
Result:
Type A, type B, and type C were found in 16 (10%), 37 (23%), and 107 (67%) lesions, respectively. Regarding the operative mode, all patients except for two patients underwent lobectomy. All patients except for one patient was diagnosed as having adenocarcinoma. Lymph node metastasis was seen in none of types A and B, in 34 (32%) lesions of type C. Lymphovascular invasion was seen in 73(68%) lesions of type C, 6 (16%) lesions of type B but not in type A. The median follow-up period was 68 (2-162) months. Recurrence was not observed in patients with type A and type B. The 5-year overall survival (OS) and disease free survival (DFS) rates were both 100% in type A, both 97.2% in type B, and 88.4%, 66.7% in type C, respectively. Patients with type C had a significantly worse prognosis than did those with the other types with respect to OS (p = 0.033) and DFS (p < 0.001).
Conclusion:
Tumors with type A and type B on TSCT showed an excellent prognosis with no lymph node metastasis. Therefore, GGO predominant lung cancer could be considered “early” lung cancer even if tumor size was larger than 3.0 cm in diameter.
