Author of

• 20163

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  P1.14 - Radiotherapy (ID 700)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Radiotherapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22769

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    P1.14-002 - Comparison Between Stereotactic and Conventional Radiotherapy for Solitary Lung Tumors After Resection of Lung Cancer (ID 7347)

    09:30 - 09:30  |  Presenting Author(s): Shigeo Takahashi
    • Abstract
    • Slides

    Background:
    No standard fractionation of radiotherapy (RT) has been established for solitary lung tumors after complete resection of non-small cell lung cancer (NSCLC). We retrospectively compared stereotactic body radiotherapy (SBRT) with conventionally fractionated radiotherapy (CFRT) with regard to efficacy and toxicity.
    
    Method:
    Between 2006 and 2015, 26 patients were treated with RT alone for solitary lung tumors that were postoperative local recurrence, pulmonary metastasis, or multiple primary lung cancer after complete resection of NSCLC. At the time of RT, 22 patients (85%) were medically inoperable. The median age was 79 years (range, 61-88 years). Histological confirmation was obtained in 4 patients (15%). The median maximum diameter of the solitary lung tumors was 15 mm (range, 6-30 mm). None of the patients had regional or extra-pulmonary distant metastasis. SBRT using 48 Gy in 4 fractions at the isocenter was administered to 15 patients with peripheral solitary lung tumors (SBRT group). CFRT using 66-70 Gy in 33-35 fractions was administered to 11 patients with central solitary lung tumors to avoid a risk of severe hilar or mediastinal toxicity with SBRT (CFRT group).
    
    Result:
    The median follow-up time was 32 months (range, 9-79 months). Regarding characteristics of the patients, adjuvant chemotherapy after surgery was significantly more often performed in the SBRT group than the CFRT group (p = 0.036; Fisher's exact test). However, adjuvant chemotherapy after surgery was not a significant factor for overall survival and local control rates after RT (p = 0.232 and 0.547, respectively; log-rank test). No other characteristics of the patients differed significantly between the SBRT and CFRT groups. The 3-year overall survival rates in the SBRT and CFRT groups were 81% and 40%, respectively (p = 0.008; log-rank test). The 3-year local control rates in the SBRT and CFRT groups were 83% and 35%, respectively (p = 0.035; log-rank test). Regarding toxicities (CTCAE v4), no significant differences in the occurrences of grade 2 radiation pneumonitis and grade 2-3 dyspnea were found between the SBRT and CFRT groups (p = 1.000 and 1.000, respectively; Fisher's exact test). No other grade 3-5 toxicities were observed.
    
    Conclusion:
    SBRT may be more effective compared with CFRT in patients with solitary lung tumors after complete resection of NSCLC.
    
    

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