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Y.R. Park



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    Epidemiology and innovations in biomarker development (ID 42)

    • Event: ELCC 2017
    • Type: Poster Discussion session
    • Track:
    • Presentations: 1
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      18PD_PR - Optimal screening interval for detection of newly developed lung cancer: Comparison of sexual difference (ID 390)

      17:25 - 17:25  |  Author(s): Y.R. Park

      • Abstract

      Background:
      The clinical and radiologic presentation of lung cancer in women differs from men, especially in Asia. The aim of this study is to identify potential gender-related differences of newly developed lung cancer and provide the optimal CT screening intervals for the patients who are managed in the health care center.

      Methods:
      Between January 2000 and February 2016, a total of 46,766 consecutive patients who underwent screening chest CT in Health Care Center at Asan Medical Center of Korea were retrospectively reviewed. During the study period, 282 patients (M:F=205:77) were finally diagnosed by lung cancer. Among them, lung cancers were detected by initial screening CT in 186 patients (excluded in this study), and 96 patients (M:F=85:11, age range M:F=62.7±12.9: 62.7±8.7 years, respectively) have been clinically diagnosed as newly developed lung cancers using subsequent screening CT follow-up. Using the 96 patients, CT screening intervals, stage, and pathology (with subtype and mutation) of cancers were evaluated and analyzed to find any gender-related differences.

      Results:
      In the 96 patients, mean age is not significantly different between genders. Most of the men were smokers (74/85, 87%). Adenocarcinoma is the most common type (36/85, 42%), followed by squamous cell carcinoma (35%), small cell lung cancer (18%), and others (5%) in men. All female patients were adenocarcinoma. The mean time interval of screening CT was relatively longer in women (5.6±3.1 years) than in men (3.6±2.4 years) (p=0.02). However, lung cancer stages are significantly higher in men. Minimum CT screening interval to detect stage I lung cancer was longer in women (5 years) compared to that in men (1 year).

      Conclusions:
      The interval of screening CT could be longer in women than men. To detect most of stage I lung cancer, a 3-year interval screening for women and 1-year interval for men are optimal in our study for minimizing radiation hazard and worry.

      Clinical trial identification:


      Legal entity responsible for the study:
      None

      Funding:
      N/A

      Disclosure:
      All authors have declared no conflicts of interest.