Author of

• 18749

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  P3.07 - Poster Session with Presenters Present (ID 493)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Regional Aspects/Health Policy/Public Health
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18755

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    P3.07-006 - Estimating Time Equivalents for Cancer Side Effects among Lung Cancer Survivors and Caregivers: A Discrete-Choice Experiment (ID 6066)

    14:30 - 14:30  |  Author(s): E. Janssen
    • Abstract

    Background:
    While there is a growing literature on estimating the tradeoffs between the benefits and risk of cancer care, there is a paucity of literature exploring preferences for the collateral damage associated with long-time side effects. We estimated the treatment preferences of lung cancer survivors and caregivers, and the time equivalents for multiple domains of long-term side effects.
    
    Methods:
    Through rigorous engagement of a national advisory board of lung cancer survivors, a discrete-choice experiment (DCE) was developed, pretested and piloted. The DCE was administered to lung cancer survivors and caregivers at a national summit. Respondents completed 13 paired-comparison choice tasks described across six attributes: progression-free survival (PFS), short-term side effects, and physical, emotional, cognitive, and functional long-term side effects. A continuous preference model was estimated using mixed logit. Using PFS as the numeraire, the preference for avoiding side-effects were estimated using their time equivalents by using maximum simulated likelihood.
    
    Results:
    Of 114 survey participants, 102 (89.4%) completed all choice tasks - although no difference was identified between those who did not complete the task (p>0.05 for all observed characteristics). All attributes were statistically different form the null (p<0.001). Respondents valued a one-unit decrease in functioning the most, valuing it equivalent to extending PFS by 3.67 months. Changes in physical (2.34) and cognitive (2.29) were valued more than a composite of all short-term side effects (1.83). Heterogeneity analyses (see figure 1) indicated that avoiding long-term side effects could be valued even more highly for some respondents. For example. the 95% confidence interval for time equivalence of functional long-term side effects ranged from 0.62 to 13.31 months.Figure 1
    
    
    
    Conclusion:
    Despite the limitation of this small, retrospective study, the results indicate that avoiding the long-term side effects could have significant value, especially as many patients experience moderate long-term side effects across multiple domains.