Author of

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  P3.06 - Poster Session with Presenters Present (ID 492)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Trial Design/Statistics
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18744

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    P3.06-005 - Blastomatoid Pulmonary Carcinosarcoma, Combined with Lepidic Adenocarcinoma (ID 5167)

    14:30 - 14:30  |  Author(s): Y. Choi
    • Abstract
    • Slides

    Background:
    Blastomatoid pulmonary carcinosarcoma is a biphasic tumor with a worse prognosis. The differenial diagnosis is pulmonary blastoma and is often challenging.
    
    Methods:
    We describe a case of blastomatoid pulmonary carcinosarcoma (BPCS), combined with lepidic adenocarcinoma in a 77-year-old female. Chest computered tomography detected a 7.5cm sized well marginated mass in right upper lobe.
    
    Results:
    Microscopically, most of the tumor (80%) revealed an immature glandular epithelium resembling high-grade fetal adenocarcinoma expressing epithelial markers and membranous beta-catenin, and blastomatoid spindle cells with extensive necrosis. Both epithelial and spindle cells expressed p53, but not thyroid transcription factor-1 (TTF-1) and Napsin-A. In focal area (20%), lepidic adenocarcinoma (LA) expressing TTF-1 was also noted. Mutation analysis revealed an EGFR mutation within LA, but, no mutation within BPCS.
    
    Conclusion:
    Blastomatoid carcinosarcoma can coexist with lepidic adenocarcinoma. However, mutation status is different between two components.
    
    

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