Author of

• 18670

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  P3.04 - Poster Session with Presenters Present (ID 474)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18681

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    P3.04-011 - Salvage Surgery for Isolated Local Recurrence after Stereotactic Body Radiotherapy for Clinical Stage I Non-Small Cell Lung Cancer (ID 5633)

    14:30 - 14:30  |  Author(s): T.F. Chen-Yoshikawa
    • Abstract

    Background:
    Non-small cell lung cancer (NSCLC) recurs locally in about 10% of the patients treated with stereotactic body radiotherapy (SBRT). The purpose of this study was to investigate the safety and outcome of salvage lung resection in these cases.
    
    Methods:
    We retrospectively analyzed the clinical data on 13 patients who underwent salvage lung resection for isolated local recurrence after SBRT between 2007 and 2014. These 13 patients were diagnosed with clinical stage I NSCLC and received SBRT (48-60 Gy) between 1999 and 2013.
    
    Results:
    All were male and the average age was 76 years (64-86) at the time of surgery. The average duration between SBRT and the surgery was 20 months (10-105). Pathological diagnosis was adenocarcinoma in 7, squamous cell carcinoma in 4, and others in 2. Lobectomy was performed in 10 patients, segmentectomy in 2 and wedge resection in 1. Because the irradiated area was mainly confined to the peripheral lungs, central pulmonary structures were intact after irradiation. There was almost no pleural adhesion related to the irradiation.There was no perioperative mortality and 4 patients had morbidities. One patient had a conversion from VATS to thoracotomy due to bleeding and 3 patients had prolonged air leak postoperatively. The resected tumor diameter ranged from 12 to 50 mm with a median of 33 mm. Viable tumor cells were found in the specimens of all patients. Two patients were positive on mediastinal lymph nodes and were offered adjuvant chemotherapy. At a mean follow-up of 52 months (range, 13 to 103 months), the 3 and 5 year survival rates were 72% and 41%, respectively.
    
    Conclusion:
    Salvage surgery after SBRT was feasible and provided encouraging outcome.