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S. Ahn



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    P3.02b - Poster Session with Presenters Present (ID 494)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P3.02b-112 - Feasibility of Re-Biopsy in Patients with Non-Small Cell Lung Cancer after Failure of Epidermal Growth Factor Receptor Targeted Therapy (ID 5557)

      14:30 - 14:30  |  Author(s): S. Ahn

      • Abstract
      • Slides

      Background:
      After failure of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), re-biopsy may be helpful to understand resistance mechanism and guide further treatment decision. However, re-biopsy is still challenging due to several hurdles, such as tissue availability, procedural feasibility, and limited new drugs. The aim of this study was to assess the feasibility of re-biopsy in advanced non-small cell lung cancer (NSCLC) in a real-practice.

      Methods:
      We retrospectively reviewed the clinical and pathologic data of advanced NSCLC patients who had disease progression after previous EGFR-TKI at single institution between January 2015 and February 2016.

      Results:
      Ninety-one patients had disease progression after using EGFR-TKI. Among them, thirty-three patients (36.3%) underwent re-biopsy. re-biopsy was successfully completed for thirty-two patients (97.0%) and only one patient didn’t get malignant cell. Three patients (9.1%) experienced a pneumothorax, however only one patient required closed thoracostomy. After re-biopsy, 27 patients were performed EGFR mutation test. Among 21 patients who had active mutation, the initial mutation was again found in 9 cases (42.9%) while the T790M mutation was found in 6 cases (28.6%). In 4 cases the initial EGFR mutation was no longer found. The patients who had re-biopsy were younger (61.2±9.7 vs. 66.1±10.8 years, p=0.03) and longer response duration (429±383 vs. 265±284 days, p=0.022) than the patients who didn’t.

      Conclusion:
      Re-biopsy in advanced NSCLC is feasible in the real practice especially in younger patient and patients with longer response duration of EGFR-TKI.

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