Author of

• 18337

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  P3.02a - Poster Session with Presenters Present (ID 470)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18359

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    P3.02a-022 - Experiences of Patients Receiving Treatment with Ceritinib to Treat ALK+ Non-Small Cell Lung Cancer: A Qualitative Study (ID 6072)

    14:30 - 14:30  |  Author(s): G. Quiggle
    • Abstract

    Background:
    Ceritinib (Zykadia) is a recently approved second-line agent for anaplastic lymphoma kinase (ALK+) non-small cell lung cancer (NSCLC). The current study sought to describe healthcare providers’ (HCPs) decisions to treat with ceritinib and to describe patient-reported side effects, perceived effectiveness and attitudes toward ceritinib.
    
    Methods:
    One-on-one telephone interviews were conducted with HCPs caring for patients treated with ceritinib using a semi-structured interview guide designed to explore treatment decision-making, adverse events (AEs) and their management. Patients with current or past experience of ceritinib completed semi-structured telephone interviews designed to capture their experience. A thematic analysis of interview transcripts was conducted using qualitative analysis software, MaxQDA.
    
    Results:
    Study participants comprised 10 HCPs (6 oncologists, 4 nurses) and 18 patients (9 female) aged 34-78 years (mean=51.0; SD=11.3). HCPs reported relying on two main factors when deciding to switch patients to ceritinib or to next-line treatment after ceritinib: evidence of sufficient clear-cut progression and poor tolerance to treatment. Four HCPs reported considering clinical trials or other newly approved drugs instead of ceritinib. Patients and HCPs concurred that the most frequently reported side effects of ceritinib include diarrhea (n=15 patients; n=9 HCPs), nausea (n=13; n=10), vomiting (n=12; n=6), and abdominal pain (n=10; n=7). Dose reduction, antiemetic and anti-diarrheal medications, and home remedies (e.g. ginger ale, crackers) were reported as being effective at managing these side effects prophylactically or once they occurred. Taking ceritinib with food was reported by 5 patients and 4 HCPs, and helped to improve nausea, vomiting or abdominal pain. Patients reported that ceritinib was effective in achieving or maintaining symptom control for cough (n=12 of 12 patients symptomatic at diagnosis) and shortness of breath (n=9 of 11 patients symptomatic at diagnosis). Of 14 patients with lung tumors at start of ceritinib, 13 reported positive tumor response during treatment. Three of 7 patients with brain metastases achieved reduction or no evidence of disease with ceritinib in combination with other interventions (e.g., radiation). Patients were asked what they liked about ceritinib: tumor response and symptom control, an extension of life, or improvement in quality of life were key themes. Patient-reported dislikes included side effects and number of pills. Of 14 patients asked specifically, all stated the benefits of ceritinib outweigh its side effects.
    
    Conclusion:
    Patients perceived ceritinib as an effective treatment for ALK+NSCLC. AEs were reported to be manageable and patients were willing to manage these in order to experience the treatment benefits.