Author of

• 18272

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  P3.01 - Poster Session with Presenters Present (ID 469)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18298

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    P3.01-026 - Clinical and Pathological Reappraisal of Primary Lung Carcer with Lymphoepithelioma-Like Carcinoma Morphology (ID 5978)

    14:30 - 14:30  |  Author(s): Y. Goda
    • Abstract

    Background:
    Lymphoepithelioma-like carcinoma (LELC) is a rare form of lung cancer, usually encountered in Chinese patients. Similar to nasopharyngeal carcinoma which is strongly associated with Epstein-Barr virus (EBV) infection, LELC is defined as a poorly differentiated carcinoma reveals EBER-positive neoplastic cells and marked lymphocyte infiltrate by 2015 WHO classification; however, EBER-negative carcinomas showing LELC-like morphology are present and such cases might be classified as adenocarcinoma or squamous cell carcinoma based on the results of immunohistochemistry staining, such as p40 or TTF-1.
    
    Methods:
    We retrospectively reviewed the medical records of 5 LELC patients who underwent pulmonary resection in Kyoto University Hospital between 2005 and 2016. All five cases were primary lung tumors with histologic features of carcinoma characterized by poorly differentiated morphology admixed with heavy lymphocyte infiltrates which fit the criteria for the diagnosis of LELC as morphologic findings.
    
    Results:
    There were 4 men and 1 woman who ranged in age from 65 to 78 years, with a median age of 70. Three patients had lymph node metastasis and underwent surgical resection, followed by adjuvant chemotherapy.One patient died of second primary lung cancer (small cell carcinoma) but four patients were alive without tumor recurrence 4 months to 8 years and 11 months.Four patients (80%) were negative for EBV, suggesting no association between EBV and LELC in our institution study group.In immunohistochemistry staining, 4 cases were positive for p40 and one case was for TTF-1.

    patient	Age	Sex	Smoking	Location	pStage	Treatment	EBER	TTF-1	p40	Outcome
    1	78	M	Yes	RUL	T1aN0M0	Surg＋adjuvant rad	negative	negative	positive	3y6m dead
    2	68	M	Yes	LLL	T1aN2M0	Surg＋adjuvant chemo	negative	negative	positive	8y11m alive
    3	71	F	None	LLL	T3N1M0	Surg＋adjuvant chemo	positive	negative	positive	6y2m alive
    4	65	M	Yes	RUL	T1bN1M0	Surg＋adjuvant chemo	negative	positive	negative	5y11m alive
    5	73	M	Yes	RUL	T1aN0M0	Surg only	negative	negative	positive	0y4m alive

    
    
    Conclusion:
    Our reexamination revealed that most LELCs were negative for EBER and were classified as squamous cell carcinoma by IHC study. This results might imply that EBER is not a requisite factor in the lung carcinoma with LELC-like morphology.