Author of

• 18272

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  P3.01 - Poster Session with Presenters Present (ID 469)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 18280

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    P3.01-008 - Clinicopathological and Immunohistochemical Features in Lung Invasive Mucinous Adenocarcinoma According to Computed Tomography Findings (ID 4576)

    14:30 - 14:30  |  Author(s): K. Shimizu
    • Abstract

    Background:
    We performed the analysis to clarify the differences of lung invasive mucinous adenocarcinoma (IMA) based on computed tomography (CT) finding, in clinicopathological and molecular features, as well as prognosis.
    
    Methods:
    On the basis of CT findings, we divided lung IMA into three subtypes; solid, bubbling, and pneumonic type. We investigated differences in clinicopathological characteristics, prognosis, and expressions of well-identified biomarkers, including Cox-2, ERCC1, RRM1, Class III beta-tubulin, TS, SPARC, PD-L1and EGFR mutation, among the three subtypes.
    
    Results:
    A total of 29 patients of resected lung IMA were analyzed. Compared with the solid or bubbling type, the pneumonic type had a higher proportion of a symptom, large tumor size, a higher pathological stage, and a significantly worse prognosis. Immunohistochemical findings tended to be high expression in RRM1, Class III beta tubulin, Cox-2 in tumor and SPARC in stroma, but not ERCC1, TS, and PDL-1 in tumor. All biomarkers in tumor were not prognostic biomarker, however, only SPARC expression in stroma was worse prognostic biomarker.
    
    Conclusion:
    Clinical and pathological features in conjunction with molecular data indicate that IMA should be divided into different subgroups. In our results, pneumonic type had significantly worse prognosis, and could guess to considered to be effective to cisplatin, pemetrexed, or nab-paclitaxel, and/or Cox-2 inhibitor. Further studies should be performed to confirm our conclusion and explore its molecular functions.