Author of

• 17783

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  P2.05 - Poster Session with Presenters Present (ID 463)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Radiotherapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17836

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    P2.05-053 - Discussion and Analysis of Pneumonitis Related to Stereotactic Radiotherapy in Our Hospital (ID 5123)

    14:30 - 14:30  |  Author(s): N. Hamanaka
    • Abstract

    Background:
    Stereotactic radiotherapy (SRT) for lung tumors and related pneumonitis have been increasing, associated with the widespread use of SRT. However, insufficient research on pneumonitis related to SRT has been reported. Therefore, we attempted to clarify the clinical features and risk factors for pneumonitis.
    
    Methods:
    Between October 2011 and 2014, 91 patients received SRT for thoracic tumors in our hospital. We carried out a retrospective analysis of their data based on medical records and chest images, and we summarized the clinical features and the presence or absence of pneumonitis.
    
    Results:
    Of 91 patients who received SRT, 62 (68.1%) were men and 29 (31.9%) were women, with a median age of 77 years. Fifty-seven (62.6%) patients were smokers and 34 (37.4%) were non-smokers. Furthermore, 17 (18.7%) patients had pre-existing pulmonary fibrosis and 48 (52.7%) had pre-existing emphysema. The target diseases treated with SRT were 62 cases of primary lung cancer and 29 cases of other diseases (e.g., metastatic lung tumor). Pneumonitis related to SRT was observed in 74 cases (81.3%). Their grades (CTCAE version 4) were as follows: 54 (59.3%) cases of grade 1, 15 (16.5%) cases of grade 2, 4 (4.4%) cases of grade 3, 1 (1.1%) case of grade 4, and no cases of grade 5. Grade 2 or more severe pneumonitis was significantly higher in patients who had pre-existing fibrosis (p=0.016). Grade 3 or more severe pneumonitis, clinically serious, was observed in 5 cases (5.5%), of which 4 were men and 1 was a woman, and 4 were smokers. In addition, 4 of them had both pre-existing fibrosis and emphysema. All were treated with steroid therapy and improved.
    
    Conclusion:
    Pneumonitis related to SRT, including mild cases, was observed frequently. Pre-existing pulmonary fibrosis is suggested to be an independent risk factor for pneumonitis caused by SRT, as well as by conventional radiotherapy. However, even severe pneumonitis was improved by steroid therapy. These observations highlight the importance of steroid therapy. We will analyze more cases, including patients under observation, and will report these data at the venue.