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A. Dimitriadou



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    P2.04 - Poster Session with Presenters Present (ID 466)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
    • Presentations: 1
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      P2.04-042 - Epithelial-Myoepithelial Tumour of Unknown Origin: An Interesting Case Report with Unexpected Outcome (ID 5513)

      14:30 - 14:30  |  Author(s): A. Dimitriadou

      • Abstract
      • Slides

      Background:
      Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them,most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of epithelial and myoepithelial elements are extraordinary infrequent, with only 20 cases in literature.

      Methods:
      We present the case of a 55 year-old man complaining for bone pain and mobility deterioration.

      Results:
      The patient was hospitalized to exclude all possible reasons of malignant bone infiltration. His X-ray scanning showed multiple lytic infiltration of unknown malignant origination. A PET/Ct scan performed did not reveal any area implying the primary malignant development. Bone biopsy taken post macro and microscopic study, diagnosis of epithelial-myoepithelial tumour was hinted. Our case has the peculiarity of being connected neither to breast nor to salivary glands as expected; a characteristic not reported in any literature reviewed case. These tumours have been named in a lot of different ways, including adenomyoepithelioma, epithelial-myoepithelial tumour, epithelial-myoepithelial carcinoma or epithelial-myoepithelial tumour of uncertain malignant potential. The p27/kip-1 protein plays a fundamental role in the development of these neoplasms. The suggested therapeutic agents are platinum/taxane combinations with not excellent prognosis and unknown outcome. The palliative care is often proposed due to the deteriorated performance status. Our patient underwent combined radiotherapy and bisphosphonate infusion with pain relief and mobility improvement. The patient, 2 years later, is still alive, under bisphosphonate support and no primary malignant has identified

      Conclusion:
      It is not rare to have prolonged outcome and satisfactory improvement in Epithelial-myoepithelial tumour even in primary malignant lesion identification. Individualized therapeutic approach is always proposed

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