Author of

• 17728

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  P2.04 - Poster Session with Presenters Present (ID 466)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17743

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    P2.04-015 - Thymoma and Thymic Carcinoma - Our Experience (ID 4731)

    14:30 - 14:30  |  Author(s): J. Kulísková
    • Abstract

    Background:
    Thymoma is most frequent epithelial neoplasm of mediastinum. It represents around 20% of primary mediastinal masses and occurs most frequently in the age of 40-60 years, affecting equally both men and women. WHO classification separates thymoma into A, AB, B1-B3 subtypes, a term ‘thymoma C’ is usually used for thymic carcinoma. Paraneoplastic symptomes may accompany thymoma frequently. Prognosis of thymoma is variable, with 5-years survival varying according to Masaoko stage (stage I 95-100%, stage IV 25%). Thymoma C represents high-grade malignancy with agressive behavior and 5-year survival around 30% (all stages).
    
    Methods:
    Present study shows five year follow up of the thymoma series from our department. 35 cases of this tumour were collected, 22 patients were eligible for complete evaluation, including histology, Masaoko stage, first- and second-line treatment, overall survival (OS) and presence of paraneoplastic symptoms.
    
    Results:
    Average age of patients was 59 years, median 61 years (17 women, 18 men). Out of 35 patients, 22 was further evaluated. Thymoma B1 subtype was most frequent (n=9/22). 1-year survival was 83% resp. 53% (operable stages I-III resp. inoperable stages III-IV), 5-year survival was 63% resp. 20%. However, in group of inoperable patients, only three patients (n=3/8) died because of disease progression, with cardiac/coronary disease being most frequent cause of mortality. Highest percentage rate of paraneoplastic symptoms was detected at thymoma B2 subtype: 100% (n=4/4), with overall frequency of paraneoplastic symptoms 45% (n=10/22). Hematological abnormalities were present at 27% (n=6/22) patients (pure red cell anemia, lymphocytosis, agranulocytosis, trombocytopenia), myasthenia gravis were detected at 13% (n=3/22) patients. Most serious paraneoplastic phenomenon was grade 4 agranulocytosis with fatal mycotic pneumonia.
    
    Conclusion:
    Despite low number of patients in present series, our data are compatible with literal figures, differing only in average age of thymoma occurence. Paraneoplastic symptoms are the characteristic feature of thymoma and can determinte the prognosis.