Author of

• 17728

  +

  P2.04 - Poster Session with Presenters Present (ID 466)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17741

    +

    P2.04-013 - Prognosis Factors and Survival Analysis in Thymic Epithelial Tumors (ID 5919)

    14:30 - 14:30  |  Author(s): A. Fernandez
    • Abstract

    Background:
    Thymic epithelial tumors (TET) include thymomas (T) and thymic carcinomas (TC). TET are rare malignant tumors usually associated with paraneoplastic syndromes (PNPS). The objective of the study is to describe our experience and to analyze the prognostic factors.
    
    Methods:
    Retrospective analysis of the clinical and pathological characteristics of 42 patients (pts) diagnosed with TET in our institution from 1990 to 2016. We analysed the outcomes in terms of progression-free survival (PFS) and overall survival (OS) and their association with clinical factors: age, perfomance status, presence of PNPS, TNM staging, WHO classification, complete resection and treatment. Kaplan Meier method and Cox regresion were used.
    
    Results:
    Mean age:55 years (27-86). 19 (45.2%) : women. First treatment: surgery in 34 pts (81%) and platinum based chemotherapy in 6 pts (14%). 2 pts (5%) were untreated. 14 pts (41%) received postoperative radiotherapy. WHO classification: 6 pts (14.3%) type A, 12 (28.6%) AB, 3 (7.1%) B1, 7 (16.7%) B2, 7 (16.7%) B3 and 7 (16.7%) C. TNM staging: 20 pts (48.8%) stage I,4 (9.8%) stage II, 6 (14.6%) stage III and 9 (22%) stage IV. 25 ptss (59.5%) had PNPS at diagnosis: 21 (50%) myasthenia gravis, 2 (4.75%) aplastic anemia and 2 (4.75%) others. Table 1 shows OS and PFS according to WHO classification:

    	WHO C	WHO: A, AB, B1, B2, B3	p value	HR (univariate)	p value
    PFS (months)(95%CI)	21.2 (5.8-36.7)	89.3(69.1-109.6)	0.03	3.12	0.04
    OS (monthS)(95%CI)	66.5 (0-157.5)	296 (98.6-493.3)	<0.001	20.2	0.007

    The presence of PNPS were associated with better OS than those without PNPS (236m , 95%CI 147-448m vs 66.5m, 95% CI 1.3-131.7m, p=0.006, HR 0.76, p=0.026 ) and also with early diagnosis (stage I for pts with PNPS 56% vs 42% without PNPS ). In the multivariate analisys, only C type remained stadistically significant (HR:13.5, p=0.024). No diferences were found when using TNM classification or complete resection.
    
    Conclusion:
    Patients with C type TET had worst prognosis. The presence of a PNPS is associated with better OS possibly due to and early diagnosis.