Author of

• 17728

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  P2.04 - Poster Session with Presenters Present (ID 466)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17738

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    P2.04-010 - Survival after Surgery and Radiotherapy for Thymic Epithelial Tumours: A Single-Centre Experience from the United Kingdom (ID 5334)

    14:30 - 14:30  |  Author(s): D. Lawrence
    • Abstract

    Background:
    Thymic epithelial tumours are rare thoracic tumours primarily treated with surgical excision. Adjuvant radiotherapy has been shown to be beneficial in locally advanced disease. There is limited published data on thymoma outcomes in the United Kingdom.
    
    Methods:
    We retrospectively reviewed records of patients who underwent thoracic surgery for thymic tumours between July 2005 and December 2015. Imaging, pathology reports and follow-up clinic records were evaluated. Kaplan-Meier curves were generated for overall survival, and the log-rank test was used for univariate survival analysis.
    
    Results:
    79 patients were identified. The median age was 58 years (range 16 - 83 years). 58% were female. 24% of patients had associated myasthenia gravis. Masaoka Stage 1 disease was most common (48%), with Stage 2a disease (27%) next in frequency. The most common histological grading was WHO B3 (33%) followed by AB (25%). 58% had surgical margins < 1 mm, with tumour at margin in 24%. 39 patients (51%) had adjuvant radiotherapy, with median follow-up of 5.1 years for these patients. A radiotherapy dose of 45 – 50.4 Gy in 1.8 Gy fractions was used. 5-year survival for the whole cohort was 68% after surgery alone, and 86% with adjuvant radiotherapy, but the difference was not statistically significant. There were no deaths during follow-up in patients who had clear surgical margins, with or without radiotherapy. If surgical margins < 1 mm, there was a trend towards improved overall survival with adjuvant radiotherapy (5-year survival 88%), compared to surgery alone (5-year survival 50%) (log-rank test chisquare 3.7, p = 0.056) (Fig. 1). Figure 1
    
    
    
    Conclusion:
    The long-term outcomes of thymic epithelial tumours are excellent after complete surgical excision. There is a trend towards improved overall survival with adjuvant radiotherapy in patients with surgical margins less than 1 mm. Routine referral of patients with close surgical margins for consideration of radiotherapy is recommended.