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J.G. Turcott
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P2.03b - Poster Session with Presenters Present (ID 465)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.03b-062 - Association of the FAACT Total Score and Subscales with Clinical Characteristics and Survival in Advanced Lung Cancer (ID 5209)
14:30 - 14:30 | Author(s): J.G. Turcott
- Abstract
Background:
Survival of lung cancer (LC) patients has increased and it is important to assess disease and treatment related symptoms that could negatively impact on prognosis and health-related quality of life (HRQL). The FAACT questionnaires have been proposed as a useful tool to measure HRQL, it includes 5 subscales: physical (PWB), emotional (EWB), functional (FWB) and social well-being (SWB), and AC/S-12 which is used to diagnose anorexia cachexia syndrome (CACS). The aim of this study was to associate the FAACT total score and subscales with clinical outcomes and survival.
Methods:
A cohort of patients with LC completed the FAACT instrument; regardless of age, gender, line of treatment, number of cycle, performance status, or histopathology subtype. Clinical and biochemical variables were collected. Survival was estimated from the day of questionnaire application until death or last follow-up.
Results:
The study included 200 patients. FAACT subscales had association with several clinical and biochemical data that are show in Table 1. PWB, FWB, AC/S-12 and FAACT total score were strongly associated to overall survival (Figure 1). Figure 1 Figure 2
Conclusion:
The FAACT questionnaire is reliable and valid for the assessment of HRQL and CACS in patients with LC and can be used liberally in clinical trials.
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P3.05 - Poster Session with Presenters Present (ID 475)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Palliative Care/Ethics
- Presentations: 1
- Moderators:
- Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)
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P3.05-002 - Malnutrition is an Independent Risk Factor on Survival on EGFR Mutated Patients Diagnosed with Non-Small Cell Lung Cancer (ID 5300)
14:30 - 14:30 | Author(s): J.G. Turcott
- Abstract
Background:
Lung cancer continues to be the leading cause of cancer-related death worldwide. In Mexico, EGFR mutation is around 31%. Malnutrition is a common problem among patients with cancer, affecting up to 85% of end-stage cancer patients, and 50-56% advanced NSCLC patients. Malnutrition poses an unfavorable prognosis and has also been associated with higher incidence of treatment related toxicity. No evidence about malnutrition in EGFR mutated patients has been described. The objective of the study is to asses the relation between malnutrition and survival of patients with NSCLC and EGFR mutation.
Methods:
One hundred-five patients diagnosed with NSCLC haring EGFR mutation undergoing any line of treatment were assessed from January 2015 to June 2016. Malnutrition was measured using the Subjective Global Assessment tool (SGA), patients were classified as without malnourishment (SGA=A) or malnourished (SGA=B+C). Overall survival was compared with the Kaplan-Meier method.
Results:
Baseline characteristics are shown in Table 1, 51.9% of patients were malnourished by the time of evaluation. Overall survival (OS) was 13.6 months (95% CI:12.7-14.4 months). Patients without malnutrition at the time of treatment initiation had a better OS than malnourished patients 14.2 vs 10.5 months (p=0.003) (Figure 1). Malnutrition is a risk factor for death independently of age, sex and treatment with TKIs versus chemotherapy (OR=8.7, 95% CI: 1.01-75.4, p=0.049).
Conclusion:
Patients harbouring EGFR mutations benefit from more effective treatments, and usually have better prognosis. Malnutrition is an independent risk factor for mortality in this population, thus assessment of nutritional status and a timely referral to a nutrition expert could result a better prognosis and health related quality of life.
