Author of

• 17556

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  P2.03a - Poster Session with Presenters Present (ID 464)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17592

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    P2.03a-036 - Response of Additional Chemotherapy, since First Line Chemotherapy in Non-Small Cell Lung Cancer (ID 4832)

    14:30 - 14:30  |  Author(s): J.H. Chang
    • Abstract
    • Slides

    Background:
    In advanced non-small cell lung cancer (NSCLC), main therapeutic modalities are chemotherapy and palliative radiotherapy. With the development of various chemotherapeutic options, the selection of chemotherapeutic agent in NSCLC subjects who showed progressive disease (PD) since 1st chemotherapy is crucial. Response of additional chemotherapy, since 1st-line chemotherapy is an important issue. The purpose of the study is the analysis of predictors on the survival of patients who received further chemotherapy since PD for 1st-line chemotherapy in NSCLC.
    
    Methods:
    It was reviewed retrospectively based on chart reviews for the 616 subjects of inoperable advanced NSCLC. Median values of overall survivals (OS) were analyzed according to gender, age, smoking history, BMI, pathology, hematologic parameters, TNM stage, response to 1st-line chemotherapy, initial chemotherapeutic regimen using univariate and multivariate analysis.
    
    Results:
    Age, sex, smoking history, pathologic type, T-stage, responsiveness to 1st-line chemotherapy, and first-line regimens were significant predictors in Log-rank test for median OS. In multivariate analysis, the patients over 65 year (hazard ratio: HR 1.53, 95% confidence interval: CI 1.02-2.30) and poor responder to initial chemotherapy (HR 1.53, 95% CI 1.06-2.20) have higher hazard ratio of death. In T stage, HR of T4 was higher than T1 (HR 2.27, 95% CI 1.01-5.11).
    
    Conclusion:
    Age less than 65 years old and responsiveness to initial chemotherapy were favorable prospecting factors for the following chemotherapy. Initial tumor stage seems to be more important than nodal status in responsiveness of chemotherapy. These factors might be helpful to prospect the outcome of following chemotherapy in advanced NSCLC.
    
    

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