Author of

• 17493

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  P2.02 - Poster Session with Presenters Present (ID 462)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Locally Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17550

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    P2.02-057 - The Importance of Adaptive Radiotherapy in the Radical Treatment of Locally Advanced Non Small Cell Lung Cancer (ID 3822)

    14:30 - 14:30  |  Author(s): L. Tadic-Latinovic
    • Abstract
    • Slides

    Background:
    Large radiation volumes and low radiation tolerance of surrounding organs of risk often limits the delivery of radical dose in the treatment of locally advanced non small cell lung cancer. Aim of this study is to quantify the disfferences between initial planning target volume and planning target volume on repeated simulation after 22-23 fractions, and consequent neeed for re-planning and adaptive radiotherapy.
    
    Methods:
    This study included 10 patients with diagnosis NSCLC, clinical stage IIIA and IIIB, in which is indicated radical radiotherapy with or without chemotherapy in period May 2015 - December 2015. Seven patients were treated with 3D conformal radiotherapy technique , and three patients were treated with IMRT technique. All patients were compared by the values of planning target volume expressed in cm[3] and equivalent spherical diameter expressed in cm[3 ] initially, and on repeated simulation after 22-23 fractions. Evaluation and need for re-planning was done by the comparation both values.
    
    Results:
    Based on the results t-test there was statistically significant difference(p<0.05) between values of planning target volume initially at the beginning of the treatment, and after 22-23 fraction. Also, based on the results t-test there was statistically significant difference (p<0.05) between values of equivalent spherical diameter initially and on repeated simulation during the course of radical radiotherapy.
    
    Conclusion:
    Adequate monitoring of clinical response and anatomical changes during course of radical radiotherapy with adequate re-simulation, re-contouring and re-planning give us possibility of reducing large radiation volumes with precise dose delivery to the planning target volume. With this concept we have possibility to improve local control and consequently minimize toxicity on organs of risk.
    
    

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