Author of

• 17493

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  P2.02 - Poster Session with Presenters Present (ID 462)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Locally Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17543

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    P2.02-050 - Gender and Smoking Influence on Non Small Cell Lung Cancer Histology and Tnm Stage in a Brazilian Population (ID 5672)

    14:30 - 14:30  |  Author(s): F.C. Abrão
    • Abstract

    Background:
    Smoking is the most important lung cancer risk factor, although its not known if this risk is equal between men and women. The objective of the study is to analyze gender and smoking influence on lung cancer in a Brazilian population who underwent surgery for non small cell lung cancer (NSCLC).
    
    Methods:
    The study population derived from the Sao Paulo Lung Cancer Registry, which began in 2014 and includes patients with NSCLC who underwent surgery with curative intention.
    
    Results:
    Figure 1 Data of 423 patients were obtained from the registry and 12 cases were excluded due to incomplete data. Out of the 411 patients analyzed, 211(51%) were women. . The resections performed were lobectomy in 324 cases (80%), pneumonectomy in 26(6%), bilobectomy 18(4%), segmentectomy 20(5%), and wedge resection in 11(3%). Women were more likely to be never smokers than men (see Table); furthermore, males smoked for a longer period and had higher load of tobacco consumption. There were no differences between genders with regard to NSCLC detection method. There was a substantially higher percentage of squamous-cell carcinoma in men than in women (27%M, 17%W, p=0,008), while adenocarcinoma and carcinoid tumors werw more frequent in women (55% W, 50% M; 19% W, 12% M, respectively, p=0,008). However, when stratified by smoking, the difference in NSCLC histologic types by gender disappears. More women had early-stage NSCLC than men (64% W, 54% M, p=0,04). In a multivariate analysis female gender was an independent factor for early stage NSCLC (OR=0,4-1,01, p=0,05), but there was no influence of age, smoking history and histologic type.
    
    
    
    Conclusion:
    Currently, more women than men have been operated on due to NSCLC in Brazil and women tend to present in earlier stages of disease. We also found a large difference in smoking habitus between genders, which can explain the differences in their histologic profile.