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Y. Yang
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P2.02 - Poster Session with Presenters Present (ID 462)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Locally Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.02-004 - Real-time Monitoring of Circulating Tumor Cells to Evaluate Response of Neoadjuvant Chemotherapy in Locally Advanced NSCLC (ID 4927)
14:30 - 14:30 | Author(s): Y. Yang
- Abstract
Background:
Enumeration and karyotyping of circulating tumor cells (CTCs) in therapeutic cancer patients is of particular clinical significance. The aim of this study is to evaluate therapeutic effect of neoadjuvant chemotherapy (NAC) by means of real-time monitoring of CTCs in locally advanced non-small cell lung cancer (NSCLC).
Methods:
Real-time monitoring of CTCs in the course of 2 cycles of platinum-based NAC was conduct in 34 locally advanced NSCLC patients. The integrated subtraction enrichment and immunostaining fluorescence in situ hybridization (SE-iFISH) method was applied to detect and characterize CTCs in peripheral venous blood. Chest CT was used to evaluate therapeutic response with RECIST 1.1 as the evaluation criterion.
Results:
Of the 34 patients enrolled, 13 acquired partial response (PR) and 21 were stable diseases (SD) after NAC. The numbers of CTCs were found decrease in 70% of PR patients and only 25% of SD patients. The changes of CTC count were significantly different between PR and SD group (p=0.009). The positive rate of CTCs with triploidy of chromosome 8 increased after 2 cycles platinum-based NAC, and the elevation was even more remarkable in SD group.
Conclusion:
The changes of CTC count after NAC were in accordance with CT responses. Triploidy of chromosome 8 CTC was correlated with primary resistance to platinum-based chemotherapy. Real-time monitoring of CTC count and karyotype may be of clinical value in rapid evaluation of therapeutic effect and monitoring occurrence of chemo-resistance.
