Author of

• 17398

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  P2.01 - Poster Session with Presenters Present (ID 461)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17485

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    P2.01-087 - Prognostic Significance of CA IX Overexpression in Stage III NSCLC Patients Received Neoadjuvant Treatment (ID 5174)

    14:30 - 14:30  |  Author(s): E. Kaytan Saglam
    • Abstract

    Background:
    The aim of study to investigate prognostic significance of carbonic anhydrase IX gene (CA IX) mRNA expression in stage III NSCLC patients received neoadjuvant treatment
    
    Methods:
    We have studied Carbonic Anhydrase IX (CA IX) mRNA expression at biopsy or surgical pathology tissues of 77 patient with Stage III A/B NSCLC received neoadjuvan treatment. CA IX mRNA expression were evaluated with 50 control .Total RNA were isolated from FFPE tissue from patients while the controls were isolated from the peripheral blood.
    
    Results:
    Median age is 56.Patients histology is 47 pts(61%)squamous cell carcinoma (SCC),30 pts(39%) adenocarcinoma(AC).Neoadjuvan Chemotherapy (NeoAdj CT)was given 45 pts(58,4%);Neoadjuvant chemoradiotherapy(neoAdjCT/RT) was given 32pts(41,6%).Median Neoadjuvan chemotherapy cycles is 3(2-6).Radiotherapy median dose was 60 Gy(45-66).Surgery outcomes is Lobectomy 38pts(49,4%);sleeve lobectomy 11 pts(14,3%),Bilobectomy 6pts(7,8%) Left pnemonectomy (18.2%),right pnemonectomy 8pts(10,4%). Recurrence rate was 39 pts(50,6%).Two year disease free (DFS) and overall survival (OS)was 59,6% and 71,4%. There was OS and DFS difference in favor of Neoadj CT 4-6 cycles versus 2-4 cycles(p=0.009 and p=0.034) There is no statistical difference(p=0,344) for CA IX mRNA expression between SCC and AC. There is no statictical difference for CA IX mRNA expression in Neoadj CT and NeoadjCT/RT groups(p=0.199). There is no statistical difference for OS between ≤Median CA IX versus ≥median groups( 20 events/39 versus 20/38 events p=0,799) There is no statistical difference for DFS between ≤median CA IX versus median groups ≥ (19 events/39 versus 20events /38)
    
    Conclusion:
    There is no any prognostic significance of Carbonic Anhydrase IX expression on DFS and OS in Stage III A/B NSCLC patients received neoadjuvat treatments.