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P. Zhou
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P2.01 - Poster Session with Presenters Present (ID 461)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.01-083 - Prognostic Factors of Overall Survival in 150 Resected Lung Adenocarcinoma Patients (ID 6060)
14:30 - 14:30 | Author(s): P. Zhou
- Abstract
Background:
The 2011 IASLC/ATS/ERS pathological calssification of pulmonary adenocarcinoma(ADC) gives new direction to clinical individualised treatment strategies and prognostic evaluation.We analyzed the prognostic effect of invasive ADC sub-types according to the new classification system.
Methods:
150 invasive lung ADCs resected in West China Hospital from 2008 to 2013 was analyzed in 5% increments, and classified and graded according to their predominant patterns, as proposed by the IASLC/ATS/ERS. Clinical data,including smoking status, chemotherapy/ radiotherapy after surgery and patient outcomes were collected.Overall survival was evaluated.
Results:
Tumor necrosis (p=0.033), poor differentiation (p=0.027), lymph node metastasis (p<0.001), surgical procedures (p=0.010), tumor diameter (p<0.001),and TNM stage (p<0.05） were significantly associated with overall survival (OS). Solid predominant ADCs (SPA) had a shorter OS than non-SPAs (43.5 vs 65.3 months, p=0.014). High-risk group (including SPA and micro-papillary predominant ADCs, MPA for short) had a poorer prognosis than low-risk group (including lepidic predominant , acinar predominant and papillary predominant ADCs, LPA,APA and PPA for short respectively) (44.4 vs 65.1 months, p=0.025). ADCs with papillary growth patterns (PP) had a better OS than those without PP (67.1 vs 42.5 months, p=0.001).In patients treated with chemo-or radiotherapy after surgery, OS of SPA and ADCs with PP were comparable to that of non-SPA and ADCs without PP ,respectively (p value>0.05). Smoking also increased the risk of poor OS in certain subtypes significantly. Multivariate analysis showed SPA, high-risk group and ADCs with PP were independent prognosis factors for OS.
Conclusion:
Growth pattern and grading system are effective prognosticators of OS in invasive lung ADCs, which also influenced by other factors like post-operative chemo-/radio-therapy and smoking status.These results will give an instruction to the future individualized treatment of lung ADCs.
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P3.01 - Poster Session with Presenters Present (ID 469)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)
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P3.01-030 - Correlation of Preoperative CT Characteristics and Histologic Patterns of Pulmonary Adenocarcinoma (ID 6074)
14:30 - 14:30 | Author(s): P. Zhou
- Abstract
Background:
Comparison of radiographic parameters and histologic sub-types of lung adenocarcinoma(ADC) proposed by the IASLC/ATS/ERS in 2011 may help to direct surgical procedures and evaluate prognosis. To analyze the relationship between them,we conducted our study.
Methods:
The architectural patterns of 197 completely resected lung ADCs were analyzed in 5% increments, and classified and graded according to their predominant patterns. Preoperative CT imaging characteristics, including lesion site, diameter, shape, margins, attenuation, cavitation, et al, were also collected.
Results:
Low-grade group(including lepidic predominant ADC, LPA) was more likely linked with vague boundary, irregular shape, vascular clusters and GGO or sub-solid nodules(SSN) , while high-grade group(including solid predominant ADC,SPA and micro-papillary predominant ADC,MPA) were vice versa (p values were 0.003, 0.037, 0.037, 0.011, respectively). More proportion of lepidic growth pattern were detected in GGOs or SSNs (p<0.001), and in those lesions characterized by the following CT features, such as vague boundary, non-lobulated margins, cavitation, irregular shape and vascular clusters(p=0.040、0.009、0.040、0.001,respectively). While the higher ratio of acinar and solid growth patterns were associated with solid lesions on CT (p=0.006, 0.020 , respectively). More proportion of Solid growth pattern were detected in spherical tumors (p=0.016).
Conclusion:
We conclude that CT imaging characteristics are associated with histo-morphological patterns of ADC to some extent. It may offer some clues for the diagnosis of ADC and predicting its survivals as well.
