Author of

• 17398

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  P2.01 - Poster Session with Presenters Present (ID 461)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 17449

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    P2.01-051 - Myeloid-Derived Suppressor Cell Expression within the Microenvironment of Lung Adenocarcinoma (ID 4779)

    14:30 - 14:30  |  Author(s): Y. Jin
    • Abstract

    Background:
    Myeloid-derived suppressor cells (MDSCs) are implicated in immune suppression of cancer and chronic inflammation. Although PD-1/PD-L1 checkpoint inhibitors show clinical efficacy as immunotherapy for lung cancer, the mechanisms by which lung cancers are refractory to immunotherapy remain to be fully understood. MDCSs are thought to contribute to T-cell exhaustion and have been proposed to play a role in tumor progression. In human lung cancer, the relationship between MDSCs and clinico-pathological factors, and the relevance of MDSCs to its diagnosis and treatment is yet to be elucidated.
    
    Methods:
    Tissue specimens were obtained from 30 surgically treated patients with stage I to IV NSCLC. Correlation between immunohistochemical staining for CD33, CD14, CD11b, CD8 and PD-L1 (SP263), and clinico-pathological factors were ebaluated. For PD-L1, membranous staining of any intensity of in more than 25% of tumor cells was considered positive. Histologic subtypes were compared with the degree of MDSCs expression.
    
    Results:
    CD33- and CD11b- positive immune cells were more highly expressed in tumor tissue than normal tissue. PD-L1 expression was detected in 23% of tumors, and it correlated with CD8-positive cells. Expression of MDSCs was more prominent in invasive adenocarcinoma than adenocarcinoma in situ, and as well as in tumor tissue compared with normal lung tissues adjacent to the tumor. Expression of MDSCs within the tumor microenvironment correlated with the stage of disease progression and subgroup of histological subtypes.
    
    Conclusion:
    These findings suggest that MDSCs expression within the microenvironment of lung cancer tissue is associated with progression of human lung adenocarcinoma.