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P. Aukrust
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P2.01 - Poster Session with Presenters Present (ID 461)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.01-002 - Serum Protein Signature in Lung Cancer Patients and in Patients with Chronic Obstructive Pulmonary Disease (ID 4153)
14:30 - 14:30 | Author(s): P. Aukrust
- Abstract
Background:
Chronic inflammation plays an important role in lung carcinogenesis and in chronic obstructive pulmonary disease (COPD), and is accompanied with alterations in specific serum-proteins. Both COPD and lung cancer are associated with smoking behavior, and 40-70% of lung cancer patients have COPD. The aim of the study is to compare levels of specific serum markers related to inflammation, extracellular matrix remodeling (ECM) and endothelial cell activation in patients with lung cancer and COPD.
Methods:
Blood samples were collected from 208 lung cancer patients with stage I-IIIA disease before surgery in addition to blood samples from 47 COPD patients, stage I-IV (4 patients in stage I, 16 in II, 19 in III and 8 in IV). Six of COPD-patients used oral steroids, 28 used inhaled corticosteroids. Serum levels of various markers were measured by enzyme immunoassays.
Results:
Of 17 proteins (table 1), 9 were significantly elevated in the COPD group compared to lung cancer group including proteins associated with lung cancer in other studies as OPG, PTX3, ePCR, GDF15 and endostatin. Only 3 proteins, CRP, vWF og GDF15 reflecting systemic inflammation and endothelial cell activation, were more abundant in serum from lung cancer patients, and one of these (CRP) significantly so.Table 1. Serum proteins measured in our study.
Protein short name Protein full name OPG Osteoprotegrin ePCR Endothelial cell protein C receptor vWF Von Willebrand factor PTX3 Pentraxin 3 Axl Tyrosine-protein kinase receptor CXCL16 C-X-C motif chemokine ligand 16 DLL1 Delta-like protein 1 Cats Cathepsin S (Chloramphenicol acetyl transferase) GDF15 Growth differentiation factor-15 Endostatin CD147 Cluster of differentiation 147 (Basigin. EMMPRIN) sTNFR1 Tumor necrosis factor receptor 1 CRP C-reactive protein Alcam (CD166) Activated leukocyte cell adhesion molecule PARC p53-associated parkin-like cytoplasmic protein sCD163 Cluster of differentiation 163 Gal3BP Galectin-3-binding protein
Conclusion:
Chronic inflammation plays an important role in both diseases: lung cancer and COPD. However, it seems that inflammation as determined by these selected markers is more pronounced in patients with COPD as most of the biomarkers levels were significantly higher in these patients than lung cancer group.
