Virtual Library
Start Your Search
M. Isaka
Author of
-
+
P1.08 - Poster Session with Presenters Present (ID 460)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
-
+
P1.08-075 - Salvage Surgery for Stage IV Non-Small Cell Lung Cancer (ID 3816)
14:30 - 14:30 | Author(s): M. Isaka
- Abstract
Background:
There have been few reports regarding salvage surgery in patients with primary lung cancer, and the efficacy of salvage pulmonary resection for primary lung cancer have not been fully elucidated. Furthermore, salvage surgery for stage IV non-small cell lung cancer have been rarely performed. The purpose of this study is to evaluate the efficacy of salvage surgery for stage IV non-small cell lung cancer.
Methods:
We performed a retrospective analysis of 4 patients who underwent salvage pulmonary resection for stage IV non-small cell lung cancer between September, 2002 and September, 2015 at the Shizuoka Cancer Center Hospital.
Results:
Of 2606 cases of surgically resected lung cancer in our hospital, 4 cases (0.15%) of salvage surgery for stage IV non-small cell lung cancer patients were performed. There were 2 men and 2 women. The range of age was 38-63 years old (median 57 years old). The histological type was 3 adenocarcinomas and one large cell carcinoma. The reasons diagnosed stage IV non-small cell lung carcinoma were 2 liver metastasis, 1 brain metastasis, and 1 abdominal lymph node metastasis. All cases have administered chemotherapy, and salvage pulmonary resection was performed for persistent or recurrent primary lung tumors. The median period for surgery from chemotherapy was 17.5 months (range 13-55 months). The lobectomy was performed in all cases. There were no complications after surgery and the mean length of hospital stay was 9 days. Postoperative disease free survival of all patients was 2, 2, 5, 52 months (median 3.5 months), respectively. 3 cases had recurred after surgery and all of them were distant recurrence. 2 cases were died of disease (survival time 15, 42 months, respectively), 1 case was alive with recurrent disease, and 1 case was alive with no recurrent disease (survival time 52 months).
Conclusion:
Although almost all cases had developed distant recurrence after surgery early, one case was long-term survival. Salvage surgery might have been effective for highly selected stage IV non-small cell lung cancer patients.
-
+
P2.02 - Poster Session with Presenters Present (ID 462)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Locally Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
-
+
P2.02-031 - Survival Data of Postoperative Adjuvant Chemotherapy of Cisplatin plus Vinorelbine for Completely Resected NSCLC: A Retrospective Study (ID 5032)
14:30 - 14:30 | Author(s): M. Isaka
- Abstract
Background:
Although the efficacy of postoperative adjuvant cisplatin (CDDP)-based chemotherapy, such as the combination of CDDP and vinorelbine (VNR) has been established for surgically resected non-small cell lung cancer (NSCLC), there has been some reports about the survival data of Asian patients treated with the combination of CDDP and VNR as adjuvant chemotherapy.
Methods:
We retrospectively have evaluated patient compliance and the safety of adjuvant chemotherapy with CDDP at 80 mg/m[2] administered on day 1 plus VNR at 25 mg/m[2] administered on days 1 and 8, every 3 weeks at the Shizuoka Cancer Center between February 2006 and October 2011 (Kenmotsu, et al. Respir Investig 2012). In this study, we evaluated survival data of these patients. Overall survival (OS) and relapse-free survival (RFS) after the start of adjuvant chemotherapy conducted by the Kaplan-Meier method to assess the time to death or relapse.
Results:
One hundred surgically resected NSCLC patients were included in this study. The characteristics of the patients were as follows: median age 63 years (range: 36–74); female 34%; never smokers 20 %; histology non-squamous/ squamous cell carcinoma 73%/ 27%; EGFR mutation mutant/ wild/ unknown 19%/23%/58%. Pathological stages IIA/IIB/IIIA were observed in 31/22/47%. The median time from surgical resection to the start of adjuvant chemotherapy was 44 days (range: 29–79 days). Median follow up was 5.6 years (range, 3.8 – 9.7 years). The five-year OS rate was 73% and the 2-year OS rate was 93%. The five-year RFS rate was 53% and the 2-year RFS rate was 62%. A univariate analysis of prognostic factors showed that patient characteristics (gender, histology, pathological stage) and dose intensity of cisplatin were not significantly associated with OS.
Conclusion:
Our results suggested that the prognosis of surgically resected NSCLC patients, who were treated with the combination of CDDP and VNR as adjuvant chemotherapy, might be better than previous results of adjuvant chemotherapies for NSCLC patients. This result can be influenced by the advances of diagnostic and surgical procedures, and the efficacy of chemotherapy including molecular target therapies.
-
+
P3.04 - Poster Session with Presenters Present (ID 474)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)
-
+
P3.04-004 - The Risk Factor of the Thrombus Formation in Pulmonary Vein Stump after Left Upper Lobectomy for Lung Cancer (ID 5105)
14:30 - 14:30 | Author(s): M. Isaka
- Abstract
Background:
It has been known that thrombosis in the pulmonary vein (PV) stump after lobectomy could possibly be the cause of embolism of vital organs including cerebral infarction. Several studies have proved that left upper lobectomy is the risk factor of thrombus forming in the PV stump. The aim of this study was to clarify the risk factors of thrombus forming in the PV stump after left upper lobectomy for lung cancer.
Methods:
At our institute, 342 patients underwent left upper lobectomy for lung cancer from September 2002 to December 2013. Among them, 296 patients who received follow-up enhanced CT after surgery were retrospectively analyzed to see whether the thrombus in the left superior pulmonary vein (LSPV) stump would be detected. We analyzed the risk factors for thrombosis formation by uni-, and multivariate analysis.
Results:
Thrombus in the LSPV stump was formed in 21 patients (7.1%). Body Mass Index (BMI) of the thrombus forming group (median, 23.64; range 20.03 to 28.99) was significantly higher than the no-thrombus-forming group (median, 22.06; range 13.37 to 30.57; p=0.022). Univariate analysis revealed that significant risk factors include high BMI (p=0.022), no history of malignant disease (p=0.045), history of ischemic heart disease (p=0.049), cut LSPV at peripheral branch (p=0.029), pN2 (p=0.005), pStage III or higher (p=0.007), and adjuvant chemotherapy (p=0.005). In multivariate analysis, only pStage III was the significant risk factor.
Table1. Multivariate Analysis of Clinicopathologic FactorsOdds Ratio 95% Confidence Interval p Value BMI 1.170 0.992 - 1.379 0.061 History of malignant disease 0.288 0.037 - 2.273 0.238 History of ischemic heart disease 3.485 0.952 - 12.756 0.059 Cut LSPV at peripheral branch 3.611 0.801 - 16.272 0.095 pStage III or IV 3.830 1.394 - 10.524 0.009
Conclusion:
Thromboses were formed frequently after left upper lobectomy for advanced lung cancer.
