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B.E. Komurcuoglu
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P1.08 - Poster Session with Presenters Present (ID 460)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.08-070 - Salvage Lung Surgery: Difficulties and Results (ID 5447)
14:30 - 14:30 | Author(s): B.E. Komurcuoglu
- Abstract
Background:
Thoracic surgeons often encounter lung resections following neoadjuvan treatments. Despite that, sometimes patients have curative chemo or/and radiotherapy treatments according to being inoperable for different reasons at the time of diagnosis. After these treatments due to residual tumour or relapses, surgery might be performed and this kind of surgery is called “salvage surgery”. This surgery has more difficulties and complications because of the adverse effects of definitive therapies. In this study we retrospectively analysed such patients undergone salvage surgery, and looked for an answer if we have to avoid or not?
Methods:
Patients operated after curative chemo or/and radiotherapy (4 cycles and more chemotherapy and 66 Gy radiotherapy is accepted as curative radiotherapy) between January 2010 and December 2014 were included in this study and analysed retrospectively. Demographic data, surgical management, morbidity, mortality and survival results were collected.
Results:
Having the described criteria 69 cases (62 male, 7 female) were included in the study. Six of the cases had chemotherapy, 8 radiotherapy only and remaining 55 had only chemotherapy (4-12 cycles). At the postoperative period, 5 cases were undergone rethoracotomy, 10 had prelonged air leakage and were externed with “Heimlich Valve” system, 5 had intraoperative vascular injury; 1 chylothorax, 4 secretion retantion requiring bronchoscopy, and 2 (2.3%) mortality occured. The mean follow up time was 27.6±20.5, ranging with 0.1-69.7 months. Five year survival was calculated as 51.9%.
Conclusion:
Complications after resective surgery following curative treatments are at acceptable rates. Besides this, the 51.9% five year survival rate seems like a last chance for such patients who have had their definitive treatment.
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P2.04 - Poster Session with Presenters Present (ID 466)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.04-048 - Sarcomatoid Carsinoma of Lung (ID 5908)
14:30 - 14:30 | Author(s): B.E. Komurcuoglu
- Abstract
Background:
Sarcomatoid carcinoma of the lung, of all lung cancers are rare tumors that account for about 0.3% to 1%. Moved across the periphery of the lungs tend to show local invasion of adjacent tissues. In the literature, it is more common in older men and other nonsmallcell is reported to have worse prognosis than lung cancer suptip. However, no large studies on this subject. Our hospital patients with a diagnosis of pleomorphic carcinoma within the last five years, radiological and pathological features were analyzed retrospectively. The average age of the patients was 64.9 'd, 2 patients were women and 16 male patients. The most common symptoms of shortness of breath, weight loss and chest pain. Bronchoscopic biopsy diagnosis in 2 cases, true-cut biopsy in 6 cases, 10 cases were diagnosed by surgical biopsy. Radiological since they tend to settle peripheral lesions and chest wall often been followed showed pleural invasion. The median survival time of the patients was 10.6 months (1 month-24 months). Pleomorphic carcinomas are rare tumors of the clinical literature that lung, radiological and pathological features are not case series highlighting the work we aimed to highlight the features of this rare group
Methods:
Retrospective analysis were made in our thoracic oncology clinic datebase.
Results:
Our hospital patients with a diagnosis of pleomorphic carcinoma within the last five years, radiological and pathological features were analyzed retrospectively. The average age of the patients was 64.9 'd, 2 patients were women and 16 male patients. The most common symptoms of shortness of breath, weight loss and chest pain. Bronchoscopic biopsy diagnosis in 2 cases, true-cut biopsy in 6 cases, 10 cases were diagnosed by surgical biopsy. Radiological since they tend to settle peripheral lesions and chest wall often been followed showed pleural invasion. The median survival time of the patients was 10.6 months (1 month-24 months).
Conclusion:
Pleomorphic carcinomas are rare tumors of the clinical literature that lung, radiological and pathological features are not case series highlighting the work we aimed to highlight the features of this rare group
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P2.06 - Poster Session with Presenters Present (ID 467)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Scientific Co-Operation/Research Groups (Clinical Trials in Progress should be submitted in this category)
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.06-044 - Frequency of Mutations and Related Factors in Lung Adenocarcinoma Cases in Turkey (ID 5291)
14:30 - 14:30 | Author(s): B.E. Komurcuoglu
- Abstract
Background:
Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 receptor tyrosine kinase (ROS1) gene mutations in lung adenocarcinoma (LA) cases give an opportunity to use some of targeted therapy agents. The aim of this study is to obtain EGFR, ALK and ROS1 gene mutation frequencies in Turkey and to examine the factors affecting these frequencies.
Methods:
EGFR, ALK, ROS1 mutation analyses were examined in a total of 971 LA cases; 745 men (76.7%), and 226 women (23.3%) diagnosed in 12 hospitals from different districts of Turkey were enrolled in the study. The demographic characteristics, smoking status, asbestos exposure history, radiological findings associated with asbestos exposure (AE) were investigated with relation to the frequencies of EGFR, ALK and ROS1 gene mutations. In the univariate analysis of the study data chi-square and t-tests were used. To determine the independent factors associated with gene mutations, multivariate logistic regression model was created with the variables that give p <0.10 level of significance in univariate analysis.
Results:
The mean age of 971 patients was 60.8±9.8 years (range:23-91). Smoking rate was 92.6% in men, 42.5% in women (p<0.001). The number of patients with AE history was 279 (28.7%) and the number of patients with radiologic findings associated with AE was 114 (11.7%). The frequencies of EGFR, ALK and ROS1 mutations were 15.9% (152/956), 3.3% (26/768) and 1.6% (6/379), respectively. Female patients were more likely to have EGFR mutations compared with male patients (37.8% versus 9.3%; p<0,001). Never-smokers had higher incidence of EGFR mutations than smokers (39.6% versus 10.3%; p<0.001). The patients with radiological findings of AE had a 24.6% rate of EGFR mutations compared with a 14.7% rate of patients with no radiological findings (p=0.007). ALK rearrengement was detected in patients with younger age, having history of AE or radiological findings associated with AE (11.1%; p<0.001, 5.9%; p=0.014, 6.7%; p=0.044, respectively). No associated factor was found with ROS1 fusion frequency.
Conclusion:
To have a relationship between radiographic findings associated with AE or AE history and EGFR and ALK mutation frequencies is an original finding. The obtained results will be useful in the discussion of standards of treatment with the new agents and pathogenesis. *This study was carried out through the project named as “Network cooperation for the management of environmental and occupational exposure to mineral fibers induced pulmonary pathologies” which was supported by General Directorate of Health Researches, Republic of Turkey, Ministry of Health.
