Author of

• 16935

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  P1.08 - Poster Session with Presenters Present (ID 460)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16953

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    P1.08-018 - Positive N Stage is a Risk Factor for Survival in Five-Year Disease Free Survivors with Completely Resected Non-Small Cell Lung Cancer (ID 3935)

    14:30 - 14:30  |  Author(s): D.J. Kim
    • Abstract

    Background:
    Lung cancer has a poor prognosis and it has a small number of long term survival patients compared to other cancers. Therefore, there is a limitation in evaluating survival beyond 5 years after surgical treatment. The purpose of this study is to analyze risk factors of survival and late recurrence in these patients after 5 years disease free period.
    
    Methods:
    This is a retrospective analysis of patients who had at least 5 years disease free survival after surgical treatment for NSCLC at a single institute between January 1998 and December 2007. We excluded patients who received neo-adjuvant therapy, incomplete resection, or advanced stage (stage IIIb and IV).
    
    Results:
    463 (41.1%) out of 1126 patients were enrolled. 318 patients (68.7%) were male, and their mean age was 61.3 ± 9.7 years (range, 21.3 – 82.2). Pathologic N0 (337 patents, 72.8 %) and stage I (263 patents, 56.8 %) were dominant stage. Late recurrence occurred in 5.4 % (25 patients) after 5 years of surgery. In multivariate analysis, male, age (≤ 60 years), node positive, and late recurrence were independent risk factors for overall survival, while the node positive was the only independent risk factor for disease free survival on multivariate analysis (HR, 2.609; p=0.017; CI, 1.190 – 5.719).

    Table. Multivariate analysis of Overall Survival & Disease Free Survival

    Variables	HR	p	95% CI
    Overall Survival
    Sex
    Female	1
    Male	2.243	0.003	1.323-3.801
    Age
    age < 60	1
    60 ≤ age <70	2.647	<0.001	1.593-4.398
    70 ≤ age	4.607	<0.001	2.605-8.149
    p-N stage
    N0	1
    N1+N2	1.809	0.003	1.231-2.660
    Recurrence
    No	1
    Yes	5.377	<0.001	3.316-8.719
    Disease free survival
    p-N stage
    N0	1
    N1+N2	2.609	0.017	1.190-5.719

    
    
    Conclusion:
    This study confirmed that late recurrence occurred in patients with no recurrence for 5 years after surgical resection, and it had a negative effect on overall survival beyond 5 years after operation. Furthermore, N positive (N1 or N2) was an independent risk factor for both overall survival and disease free survival. Therefore, careful follow-up is needed for the detection of late recurrence even in patients with five years disease free survival, and especially for node-positive patients. More studies are needed to clarify this point.