Author of

• 16935

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  P1.08 - Poster Session with Presenters Present (ID 460)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16936

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    P1.08-001 - Log Odds as a Novel Prognostic Indicator Superior to the Number-Based and Ratio-Based Category for Non-Small Cell Lung Cancer (ID 3913)

    14:30 - 14:30  |  Author(s): P. Rudzinski
    • Abstract
    • Slides

    Background:
    The paper aimed to compare the efficacy of log odds (LODDS) compared to a classification based on the number of positive lymph nodes (pN) and lymph node ratio (LNR).
    
    Methods:
    Material was collected retrospectively from an online survey-based database of the Polish Lung Cancer Group and included a group of 17369 patients who received radical surgical treatment (R0) due to lung cancer. The follow-up period was between 11.4 and 66.0 months (median 30.1 months).
    
    Results:
    In the whole group the median survival for N0, N1 and N2 was 76.1, 41.7 and 24.2 months, respectively. The median survival for individual LODDS categories (-6,-4], (-4,-3], (-3,-2], (-2,-1], (-1,0], (0,1] and (1,2] was 76.5, 76.3, 71.7, 45.4, 25.0, 19.1 and 17.7 months, respectively. The median survival for LNR in individual categories (0), (0,0.25], (0.25,05], (0.5,075] and (0.75,1.0] was 75.6, 40.3, 24.1, 18.8 and 16.4 months, respectively. When comparing LODDS and LNR significant heterogeneity can be seen that is especially visible in categories (0), (0,0.25] LNR, where 4 LODDS categories were distinguished. A multi-variant analysis demonstrated that each LODDS category is an independent prognostic factor: (-4,-3] (HR = 0.982; 95% CI 0.867-1.112; P = 0.775), (-3,-2] (HR = 1.114; 95% CI 0.984-1.262; P = 0.089), (-2,-1] (HR = 1.241; 95% CI 1.080-1.425; P = 0.002), (-1,0] (HR = 1.617; 95% CI 1.385-1.887; P < 0.0001), (0,1] (HR = 1.918; 95% CI 1.579-2.329; P < 0.0001) and (1,2] (HR = 2.016; 95% CI 1.579-2.573; P < 0.0001).
    
    Conclusion:
    Based on LODDS it is possible to discriminate patients with regard to lung cancer stage more effectively compared to pN and LNR classification, and it is also a better classification system. Therefore, a new system of lung cancer classification based on LODDS should be considered.
    
    

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