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J. Zaini



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    P1.06 - Poster Session with Presenters Present (ID 458)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P1.06-016 - Pulmonary Tuberculosis among Newly Diagnosed-Therapy Naive Advanced NSCLC  in Persahabatan Hospital Jakarta Indonesia (ID 5886)

      14:30 - 14:30  |  Author(s): J. Zaini

      • Abstract

      Background:
      The prevalence of lung cancer increased in the recent years in Indonesia, meanwhile pulmonary tuberculosis (TB) is still a major public health problems in this community. Malignancy such as lung cancer increase the risk of tuberculosis infection and reactivation, therefore evaluation of tuberculosis among lung cancer patients is needed

      Methods:
      Newly diagnosed, therapy-naive advanced NSCLC subjects were enrolled from a referral respiratory hospital Persahabatan Hospital Jakarta Indonesia between 2014-2015. Active pulmonary tuberculosis were diagnosed by Xpert MTB/ RIF from induced sputum and LPA M. TB culture. Latent Tuberculosis Infection (LTBI) was determined by Quantiferon-TB Gold-In-Tube (QFT-GIT). Demographic and clinical characteristics were evaluated.

      Results:
      Of 50 lung cancer subjects enrolled, 30 (60%) men with mean of age 55 years old (31- 74 years old). Eighty five percents were adenocarcinoma (42 subjects) and 15% squamous cell lung cancer. Most of them were at end stage (87% stage IV and 13%stage IIIB) with WHO performance status (PS) 1 to 3 (20 % PS 1, 70% PS 2 and 10% PS 3). Comorbidities among this group were COPD (3 ssubjects), diabetes mellitus (2 subjects), hypertension (4 subjects), congestive heart failure (1 subjects). Active tuberculosis were diagnosed in 2 % (1 subject). Based on Quantiferon results, 14 % were positive (7 subjects) and classified as latent tuberculosis infection (LTBI); 60% (30 subjets) classified as non-LTBI (negative Quantiferon result) but 12 (24%) indeterminate cases. The characteristics of LTBI patients were 67% men, two third were adenocarcinomas, 80% stage IV of lung cancer, 80% having WHO PS 2 and 3, 50% were underweight (body mass index (BMI) < 17.5.

      Conclusion:
      Active pulmonary tuberculosis and latent tuberculosis infection is common among newly diagnosed therapy naive advanced NSCLC in this population. Most of them are men, adenocarcinoma, PS 2-3, and half of them were underweight.

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    P3.02b - Poster Session with Presenters Present (ID 494)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P3.02b-004 - EGFR Mutation in Squamous Cell Advanced NSCLC in Persahabatan Hospital, Jakarta Indonesia (ID 5878)

      14:30 - 14:30  |  Author(s): J. Zaini

      • Abstract

      Background:
      Tyrosine kinase domain gene mutations of the epidermal growth factor receptor gene (EGFR) have proven to be clinically significant in nonsmall-cell lung cancer (NSCLC), particularly in adenocarcinoma. However, EGFR mutations in other type of lung cancer such as squamous cell lung cancer is uncommon.

      Methods:
      This is a preliminary study of which EGFR mutations were investigated using mutation-specific High Resolution Melting (HRM) polymerase chain reaction (PCR) from cytologic samples of squamous cell lung cancer. Cytological samples were obtained from bronchoscopy or transthoracal needle biopsy. Trained lung pathologist determined the cytological type of the tumor as squamous cell lung cancer. Immunohistological evaluation were not done since the cytological sample were limited.

      Results:
      Twenty subjects with confirmed squamous cell lung cancer were enrolled between June 2014 -December 2014 in Pulmonary Refferal Hospital/ Persahabatan Hospital Jakarta Indonesia, of which 18/20 (percents) were male, age between 50-75 years old. Eighty percents subjects has stage IV/metastatis with Performance Status of 2-3 at the time of diagnosis. EGFR mutations were detected in 4 of 20 subjects (20%) . Two subjects harbour exon 19 deletion, and 2 subjects harbour L858R mutation.

      Conclusion:
      These results suggest that EGFR mutations are found in 20% cytologically confirmed squamous cell lung cancer in this group.