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N. Urman
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P1.06 - Poster Session with Presenters Present (ID 458)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.06-009 - Determining Optimal Array Layouts for Delivering TTFields to the Lungs Using Computer Simulations (ID 4530)
14:30 - 14:30 | Author(s): N. Urman
- Abstract
Background:
Tumor Treating Fields (TTFields) are low intensity, alternating electric fields in the intermediate frequency range. TTFields disrupt mitosis by interfering with formation of the mitotic spindle. The therapy is FDA approved for the treatment of glioblastoma (GB). A study to assess the efficacy of TTFields in combination with chemotherapy for the treatment of mesothelioma is underway, and a pivotal study testing the efficacy of TTFields in NSCLC is planned. TTFields are delivered through two pairs of transducer arrays applied to the patient's skin. In-vivo and In-vitro studies suggest that treatment efficacy increases with field intensity. Therefore personalizing the array placement to deliver optimal field distributions is important and is a prerequisite when treating GB patients. However, optimal array layouts for lung cancer patients have not yet been determined. Here we present a finite element simulations-based study investigating optimal array layouts in male and female anatomic models.
Methods:
The study was performed using the Sim4Life software package and the DUKE and ELLA computational models (ZMT, Zurich, Switzerland). To represent individuals with a variety of body dimensions, the models were linearly scaled. The distribution of TTFields within the thorax of these models was calculated for a set of array layouts. The layouts were ranked with highest scores for those that conformed well to body contours and delivered uniform high intensity fields to the lungs.
Results:
Uniform field distributions within the lungs are obtained when the arrays are axially-aligned with the parenchyma as much as anatomically possible. Generally, the layouts that received the highest scores were those in which one pair of arrays delivered an electric field from the anterolateral to the posterior-contralateral aspect of the patient, with the second pair inducing the field from the antero-contralateral to the posterolateral aspect of the patient. However, due to body contours, this type of layout does not adhere well to smaller females, potentially hampering the efficient delivery of TTFields. Therefore, for smaller females, a layout in which one pair of arrays is placed on the lateral and contralateral aspects of the patients, and a second set of arrays is placed on the anterior and posterior aspects of the patient is preferred.
Conclusion:
This study provides important insights into how TTFields distribution in the lungs is influenced by the array layout. These results should be accounted for when developing guidelines for transducer array placement on the thorax.
