Author of

• 16751

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  P1.05 - Poster Session with Presenters Present (ID 457)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16806

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    P1.05-055 - Risk Factors of Postoperative Recurrence in Stage IA and IB Patients (ID 5606)

    14:30 - 14:30  |  Author(s): M. Katahira
    • Abstract

    Background:
    The 5-year survival rates of the patients with pathological stage IA and IB NSCLC have been reported 86-93% and 67-84%, respectively. Among stage I disease, patients with stage IA of tumor diameter over 20 mm as well as stage IB are recommended to take oral UFT as adjuvant chemotherapy for 2 years in Japan. Even after complete resection and such adjuvant therapy, we still observe recurrence at a certain rate. Identifying clinicopathological factors which is associated with recurrence would be beneficial to establish alternative strategy. The purpose of this study is to identify the predictive factors for recurrence in the patients with stage I NSCLC.
    
    Methods:
    A total of 742 stage I NSCLC patients who underwent complete resection in our hospital from 1996 to 2012 were retrospectively analyzed. Medical records of these patients were reviewed carefully. The median age was 66.4 years with 512 stage IA and 281 stage IB. Histopathologically, there were 590 adenocarcinoma, 150 squamous cell carcinoma, 32 large cell carcinoma, and 21 other histology cases.　Surgical procedure was segmentectomy, lobectomy, and pneumonectomy for 46, 588, and 8 patients, respectively. Clinicopathological factors such as smoking history, histology, pathological vascular invasion (v), and lymphatic vessel invasion (ly) were analyzed.
    
    Results:
    Recurrence occurred in 132 cases. Multivariate analysis showed that T factor, v(+), ly(+), and smoking history have statistical significance with recurrence. n pT1a and T2a cases, there were no statistical significance between recurrence and pathological ly(+) and/or v(+). But only in T1b cases, ly(+) and/or v(+) had statistical significance with recurrence.
    
    Conclusion:
    We identified that T factor, v, ly, and smoking history were predictive factors for recurrence in stage IA and IB NSCLC patients. Because of good prognosis, pT1b patients whose both v and ly were negative may not take UFT as adjuvant chemotherapy.