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H.R. Kim
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P1.05 - Poster Session with Presenters Present (ID 457)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.05-038 - Patterns of Recurrence in Curatively Resected Stage I Lung Cancer (ID 6300)
14:30 - 14:30 | Author(s): H.R. Kim
- Abstract
Background:
The patterns of recurrence after curative resection for pathologically stage I non-small cell lung cancer(NSCLC) were investigated according to the cell type.
Methods:
The medical records of stage I NSCLC patients who undergone curative resection at Asan Medical Center between 2000 and 2009 were reviewed.
Results:
Total 940 patients with pathologically proven stage I NSCLC were included. Patients with lepidic-type adenocarcinoma(LTA) were 74, other adenocarcinoma(ADC) 580, and squamous cell carcinoma(SCC) 246. Median length of follow-up was 62 months(3~189), median survival was 146 months, and median disease-free survival(DFS) was 109 months. During follow-up, recurrence occurred in 221 patients(23.5%). Number of recurrence is grouped by every 6 months. Incidence of recurrence was peaked within 2 years after resection, then gradually decreased thereafter. Recurrence LTA(AIS/MIA) group was significantly rare(13.5%) throughout the all follow-up period(median DFI of 60months), and its distribution shows relatively even distribution. Comparing ADC and SCC, ADC seemed to show better 5-year OS in univariate analysis(p=0.003), but not in multivariate analysis. Furthermore, there were no significant difference in 5-year DFS(p=0.331). ADC shows higher proportion of distant metastasis, even though ADC group has lower T-stage. SCC shows higher incidence of local recurrence. Figure 1
Conclusion:
Recurrence of ADC occured within 2 years after resection, and shows higher proportion of distant metastasis(74.0% Vs. 57.2) even though ADC group has lower T-stage. Most of recurrence of both ADC and SCC groups were peaked within 2 years after resection. LTA group shows significantly delayed pattern of recurrence.
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P1.08 - Poster Session with Presenters Present (ID 460)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.08-063 - Double Primary Malignancies Involving Lung Cancer and Hepatocellular Carcinoma (ID 6361)
14:30 - 14:30 | Author(s): H.R. Kim
- Abstract
Background:
The incidence of double primary malignancies (DPM) with lung cancer and hepatocellular carcinoma (HCC) has increased in gradually. However there was a lack of data about the clinical outcomes and factors. We performed a retrospective study to investigate overall survival and characteristics in that patients.
Methods:
Between January, 2002 and December, 2013, total 52 patients had DPM. 7 patients were excluded because there was lack of medical record. 3 patients with other malignancies were excluded. We divided the patients into 2 groups. 19 patients were synchronous group that interval of diagnosis between 2 malignancies was shorter than 180 days and other 23 patients were metachronous group.
Results:
Among 42 patients with DPM, there were no significant differences in basic characteristics. Median overall survival was 118.97 ± 6.39 months. There was no significant difference in overall survival between synchronous group and metachronous group (p = 0.921). Multivariate analysis revealed that higher lung cancer stage, postoperative therapy due to lung cancer, liver cirrhosis, and history of hypertension were independent factors for overall survival. Figure 1 Figure 2
Conclusion:
Lung cancer stage and underlying liver cirrhosis were strongly related to overall survival in patients with DPM involving lung cancer and HCC. Absence of hypertension showed better prognosis in those patients.
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P3.04 - Poster Session with Presenters Present (ID 474)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 2
- Moderators:
- Coordinates: 12/07/2016, 14:30 - 15:45, Hall B (Poster Area)
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P3.04-010 - Changes of Right Lung Volume after Right Upper Lobectomy for Lung Cancer (ID 5630)
14:30 - 14:30 | Author(s): H.R. Kim
- Abstract
Background:
Many surgeons routinely perform the division of the inferior pulmonary ligament (IPL) during the right upper lobectomy for lung cancer. It is believed that the division of the IPL can facilitate mobilizing and expanding residual lobes, and decreasing dead space. We aimed to evaluate the volume changes of the right middle lobe (RML) and the right lower lobe (RLL) after right upper lobectomy according to IPL division.
Methods:
We performed a retrospective analysis of the medical records and images of 181 patients with lung cancer who had underwent right upper lobectomy via a video-assisted thoracic surgery (VATS) in Seoul Asan Medical Center from May 2009 to December 2013. The IPL was preserved in 76 patients (Group A) and was divided in 105 patients (Group B). Using in-house software with chest computed tomography (CT), we compared the difference volume changes of pre- and post-operative RML and RLL between the two groups.
Results:
There were no significant differences between the two groups in terms of age, sex, height, tumor size, chronic obstructive pulmonary disease and smoking status. In group A, the adjusted mean volume change of difference RML (dRML) and difference RLL (dRLL) were -0.45 mL/kg and 6.03 mL/kg, respectively. In group B, the adjusted mean volume change of dRML and dRLL were -0.55 mL/kg and 5.28 mL/kg, respectively. The difference was not significant.
Conclusion:
Division of the IPL during the right upper lobectomy is not beneficial technique regarding remnant lung volume.
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P3.04-024 - Long-Term Outcome of Sublobar Resection versus Lobectomy for Stage I and II Non-Small Cell Lung Cancer (ID 6182)
14:30 - 14:30 | Author(s): H.R. Kim
- Abstract
Background:
Lobectomy is conventional lung resection surgery for lung cancer. However, the patients who have poor lung function or small size lung nodule underwent sublobar resection. We retrospective reviewed the oncologic outcome after sublobar resection lobectomy in stage I and II non-small cell lung cancer.
Methods:
1019 consecutive patients who underwent lung resection surgery due to non-small cell lung cancer between January 2000 and December 2009 were evaluated through retrospective chart review. We used the Kaplan-Meier method to exam survival and recurrence, Cox proportional hazard model to identify variables affection survival and recurrence.
Results:
We performed lobectomy in 928 patients, while sublobar resection in 90 patients. 5-year survival and 10-year survival were not shown statistically significant between sublobar resection and lobectomy (77.0% vs. 80.7%, 58.5% vs. 62.1%, p=0.566). 5-year and 10-year disease free survival were not also shown the difference between sublobar resection and lobectomy (68.9% vs. 63.8%, 67.8% vs. 58.7%, p=0.246). Univariate analysis using the Cox proportional hazards regression model identified sublobar resection is not predicting factor for recurrence (p=0.246).
Conclusion:
Our results suggest that the oncologic outcome of sublobar resection versus lobecotomy is not significant difference in stage I and II non-small cell lung cancer patients. These results will be validated by prospective randomized trial.
