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P. Zanen
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P1.05 - Poster Session with Presenters Present (ID 457)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.05-032 - Quality of Life after Stereotactic Body Radiotherapy and Surgery in Patients with Early Stage Non-Small Cell Lung Cancer (ID 4947)
14:30 - 14:30 | Author(s): P. Zanen
- Abstract
Background:
Several studies have shown that the clinical outcomes after stereotactic body radiotherapy (SBRT) are not inferior compared to surgery in patients with early stage non-small cell lung cancer (NSCLC). Quality of life (QoL) after treatment is an important parameter for patients which receives raising interest. We compared the QoL during the first year after treatment in patients with early stage NSCLC.
Methods:
Patients diagnosed with early stage NSCLC and treated with SBRT or surgery in the Sint Antonius Hospital between 2013 and 2015 were included. QoL assessments were performed before treatment, and at three, six and 12 months after treatment. QoL was evaluated by using the 30-item European Organization for Research and Treatment of Cancer Quality of life Core questionnaire and its corresponding 13-item lung cancer supplement. A linear mixed model was used to analyse the data and a change of more than five points was determined as minimal clinically important difference .
Results:
Ninety-three patients were included (SBRT n = 39, surgery n = 54). Patients who underwent SBRT were significantly older, had a higher ECOG performance status and a lower pulmonary function. The compliance for SBRT and surgery at baseline were 97% and 98% (p = 0.8), at three months 74% and 71% (p = 0.8), at six months 62% vs 78% (p = 0.1), and at 12 months 45% and 73% (p = 0.04). The ECOG performance status was not significantly different between the patients who were compliant and those who were not compliant. During the 12 months after treatment different significant changes were observed: QoL remained stable in SBRT patients and increased in surgical patients (p = 0.012) Role functioning increased in SBRT patients and decreased in surgical patients (p = 0.005) Cognitive functioning increased in SBRT patients and remained stable in surgical patients (p = 0.045) Social functioning remained stable in SBRT patients and decreased in surgical patients (p = 0.001) Pain increased in SBRT patients and decreased in surgical patients (p = 0.001) SBRT patients had a decrease in effect of pain medication and surgical patients had an increase in effect of pain medication (p = 0.0001).
Conclusion:
We showed that in patients with early stage NSCLC treated with SBRT or surgery the QoL scores showed different changes after treatment. In the light of the comparable clinical outcomes after both treatments these QoL aspects should be discussed with the patient before making a treatment-decision.
