Author of

• 16751

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  P1.05 - Poster Session with Presenters Present (ID 457)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16774

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    P1.05-023 - Induction of Patient-Derived Xenograft Formation and Clinical Significance for PD-L1 in Lung Cancer Patients (ID 4668)

    14:30 - 14:30  |  Author(s): Y. Ma
    • Abstract
    • Slides

    Background:
    The relevance of programmed cell death ligand 1 (PD-L1) to patient-derived xenograft (PDX) formation and clinicopathological characteristics in early stage lung cancer was studied
    
    Methods:
    Cell counting kit-8 and flow cytometry were carried out to examine proliferation and apoptosis in PC9 and H520 cells transfected with siRNAs. Nod-scid mice were used to establish PDX. Immunohistochemistry was done to investigate PD-L1 expression in tumor tissues.
    
    Results:
    Proliferation was reduced and apoptosis was induced when PD-L1 was inhibited in the cells. Higher PD-L1 expression rate was observed in the primary tumors with PDX formation than in the tumors without PDX formation. Moreover, PD-L1 was found to be related to smoking, histological types, stages and overall survival in 209 of lung cancer patients.
    
    Conclusion:
    This study suggests that PD-L1 promotes PDX formation ability and is an independent prognostic marker for the early stage lung cancer patients.
    
    

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