Author of

• 16722

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  P1.04 - Poster Session with Presenters Present (ID 456)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Pulmonology
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16749

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    P1.04-027 - Changes in Pulmonary Function in Lung Cancer Patients after Thoracic Surgery (ID 5619)

    14:30 - 14:30  |  Author(s): S. Campainha
    • Abstract

    Background:
    Surgery is considered the first line treatment for patients with resectable early non-small cell lung cancer (NSCLC). Many of these patients present limited lung function which is caused by a common etiologic factor - cigarette smoking. The evaluation of pulmonary function preoperatively is important to identify candidates at risk of postoperative respiratory complications and may assist in operability decision. However, lung function after surgical resection may be affected by several factors. Objective: To evaluate changes in pulmonary function after thoracic surgery, in patients with solitary nodules or lung cancer.
    
    Methods:
    Retrospective study of patients diagnosed with operable lung cancer and solitary nodules followed in our centre between 1[st] January 2011 and 31[th] December 2014. Patients presenting pulmonary function tests (PFTs) until one year after surgery were included. Patients without PFTs after surgery were excluded.
    
    Results:
    Forty three patients were included. The results are presented in the table:

    Mean age	62±9 years
    Gender	67,4% (n=29) male
    Indications for surgery Adenocarcinoma Carcinoid tumour Squamous cell carcinoma Solitary pulmonary nodule	44,2%(n=19) 14%(n=6) 11,6% (n=5) 25,6% (n=11)
    Clinical staging in lung cancer patients IA IB IIA IIIA	43,7% (n=14) 15,6% (n=5) 12,5% (n=4) 18,7% (n=6)
    Location of the lesion Superior right lobe Superior left lobe	34,9% (n=15) 25,6% (n=11)
    Neoadjuvant chemotherapy Neoadjuvant radiotherapy	20,9% (n=9) 4,7 (n=2)
    Open surgery Video-assisted thoracic surgery (VATS)	83,7% (n=36) 16,3%(n=7)
    Comorbidities Chronic Obstructive Pulmonary Disease (COPD) Ischemic Heart Disease (IHD)	30,3% (n=13) 4,7% (n=2)
    Smoking habits Smoker Ex-smoker Non-smoker	37,2% (n=16) 32,6% (n=14) 30,2% (n=13)

    The mean values of FVC (L), FEV1 (L), FEV1/FVC and DLCO decreased after surgery (p=0.010, p=0.001, p=0.011 and p=0.037, respectively). FVC (L) and FVC (%) values decreased more significantly in patients submitted to pneumonectomy (p=0.004 and p=0,047). There was, though, an improvement of FVC (%) in patients submitted to VATS and wedge resection (p=0.005 and p=0.034). FEV1 (L) mean values increased in patients submitted to wedge resection (p=0.017) and decreased in patients submitted to pneumonectomy (p=0.04). There was no significant association between histological type, clinical stage, local of the lesion, COPD and CVD and lung function parameters before and after surgery.
    
    Conclusion:
    The postoperative pulmonary function varied according to the type of surgery, therefore the surgical procedure adopted may help us predict changes in lung function after lung surgery. Clinicians should be aware of these changes when determining the surgical method, especially in high-risk patients.