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I. Bani
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P1.04 - Poster Session with Presenters Present (ID 456)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Pulmonology
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.04-020 - Management of Lung Cancer in Patients with past Pulmonary Tuberculosis and Their Possible Causative Link (ID 4170)
14:30 - 14:30 | Author(s): I. Bani
- Abstract
Background:
Lung cancer and tuberculosis cause significant morbidity and mortality worldwide. In the past, it was well known that lung cancer is a specific epidemiological successor of pulmonary tuberculosis (PTB) and that it often develops in scars caused by PTB. In recent years, the relevance of the two diseases has drawn attention in terms of the close epidemiological connection and chronic inflammation-associated carcinogenesis. Although studies have found a relationship between PTB and lung cancer, results for the long-term risk and the role of confounding factors remain inconclusive. Therefore, it is important to delineate the relationship between PTB and lung cancer.
Methods:
Clinical files of all patients diagnosed with lung malignancy between 2011 and 2016 were investigated retrospectively in terms of patient characteristics, definite histopathological diagnosis and stage of tumor, operation methods, and associated complications.
Results:
Mean age was 56.4 years. Past PTB was detected in 3% of operated carcinoma patients and in 6% of all patients diagnosed with lung malignancy. Central lung cancer was diagnosed in 80% of cases and peripheral in 20%. Epidermoid cancer was diagnosed in 51% of cases, adenocarcinoma in 24% and adenoepidermoid carcinoma in 25%. All cases of operable lung cancers were in stage I and II, while inoperable lung cancers were in stage IIIB and IV. Lobectomy was performed in 100% of the operated cases. None of the patients received anti-TB treatment preoperatively or postoperatively because by the time they were diagnosed with lung cancer, their sputum culture for M.Tuberculosis had converted negative. No postoperative mortality or reactivation of TB was seen.
Conclusion:
PTB is an important risk factor for lung cancer, possibly related to chronic inflammation and shared risk factors. Our study adds to the evidence that implicates chronic inflammation and pulmonary scarring in the etiology of lung cancer. However, further studies are needed to clarify whether there is a direct causative link between PTB and lung cancer. Surgery is the method of choice in treatment of lung cancer in subjects with past PTB history.
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P1.08 - Poster Session with Presenters Present (ID 460)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.08-030 - Female Lung Cancer and Our Five Year Experience (ID 4627)
14:30 - 14:30 | Author(s): I. Bani
- Abstract
Background:
Lung cancer is one of the leading causes of mortality in the world. The incidence of lung cancer in females is increasing, in contrast to that seen in males. However, according to a lot of publications, lung cancer is almost six times more frequent in men than in women. The literature shows clearly that lung cancer in women differs from that in men in several aspects and environmental factors and lifestyle plays an important role in the female lung carcinogenesis. The objectives of this study were to evaluate clinic-morphologic features of lung cancer in women and the role of the surgery in their treatment.
Methods:
This was a descriptive retrospective study, conducted for five years. We analyzed all patients hospitalized diagnosed and treated for lung cancer and using Pearson Chi-Square test.
Results:
The ratio men to women for patients diagnosed with lung cancer was 8 to1.The most common histotype was Adenocarcinoma 76%, Squamous cell carcinoma 11%, Small cell carcinoma 5%, others 8%.The average age was 57.5 with SD±12 years. 6% of females were in I stage, 22% of them were in II stage, 15% of them were in IIIA stage, 10% of them in IIIB stage and 47% in IV stage. Only 9% of our patients were smokers. Dyspnea was the main clinical sign, found in 67% of women. The standardized incidence of female lung cancer patients was 5/100.000. The surgery was performed in 20% of them meanwhile in men it was performed in 12.5% of cases.
Conclusion:
Most of women diagnosed with lung cancer were in advanced stages. Adenocarcinoma is the common histotype. This study shows that lung cancer in female is eight time less frequent in women than in men. Since the ratio men to women regarding to being operable is in the favor of women because they are diagnosed earlier comparing to men, women are more subject of surgery. Because the clinical signs of lung cancer are far from being specific, a substantial portion of lung cancer cases and deaths could be prevented by applying effective prevention measures, such as tobacco control and the use of early detection tests.
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P2.04 - Poster Session with Presenters Present (ID 466)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.04-045 - Management of Malignant Pleural Effusions: Ten Years Experience of a Single Center (ID 4631)
14:30 - 14:30 | Author(s): I. Bani
- Abstract
Background:
Malignant pleural effusions (MPE) are a common clinical problem for patients with neoplastic disease. MPE may be an accompanying sign of them and sometimes the first sign. This study is an overview of diagnosis and treatment of MPE and its aim is to assess the role of invasive procedures in management of such patients.
Methods:
This is a retrospective study for a period of ten years where have been examined all clinical cartels of patients with pleural effusions. All date are analyzed with Pearson Chi-Square test.
Results:
This study has demonstrated that MPE represent 10 % of all pleural effusions. 46% of them have been smokers. 53% of MPE was in the right hemithorax, 38% in the left hemithorax and only 9% was bilateral. The age range was (18-91), and the average age was 63 years old. 37% of these patients have had recent surgery for neoplasia, and in 27% there is no information for recent malignancy and pleural fluid was the first sign of patients. 14% of these patients have relatives with neoplasia. 48% of the cases underwent to biopsy via Video Assisted Thoracic Surgery (VATS) meanwhile for the others the diagnosis was decided by fibrobronchoscopy. In 90% of cases the definitive surgical treatment was pleural drainage and chemical pleurodesis(sol betadine 20 ml + sol NaCl 0,9% 80 ml), in 5% of cases the patient underwent to partial pleurectomy and in 5% of cases wasn’t performed any surgical procedure. Hospitalization day average was 9 days. Performance status was: in 60.2% of cases improved, in 37.2% of cases the same and 2.3% of cases died in hospital. Positive result of pleural biopsy was in 97% of cases. The main hystotype was Adenocarcinoma of lung in men (35% of cases) and Ductal carcinoma of breast (18% of cases) followed by Adenocarcinoma of lung (10% of cases) in women. Mesotelioma was found in 7% of cases.
Conclusion:
Pleural fluid analysis and cytology should continue to be a first-line investigation to screen out the suspiciously MPE cases, as it is a very convenient, cost-effective and safe investigation. Its combination with pleural biopsy through VATS represents the key of success in diagnosing pleural malignant lesions. The most appropriate surgical treatment for MPE seems to be pleural drainage and chemical pleurodesis because of their origin mostly extrapleural malignancy.
