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Z. Pupla
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P1.04 - Poster Session with Presenters Present (ID 456)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Pulmonology
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.04-006 - Second Primary Lung Cancer: Five Years of a Single Center Experience in Its Diagnosis and Treatment (ID 4626)
14:30 - 14:30 | Author(s): Z. Pupla
- Abstract
Background:
Second primary lung cancer (SPLC) constitute an important dimension of the burden of cancer survivorship that needs to be taken into account when defining strategies for surveillance, prevention and counseling. In last three decades the incidence of SPLC in patients that had a history of a prior cancer out of the respiratory system is estimated 2-8%. Relative risks of SPLC may be smaller than previously reported may benefit from increased surveillance. The goal of this study was to give an overview of SPLC regarding patients’ primary malignancy, their stage of lung cancer presentation and bringing to the light some possible risk factors. Such data will be helpful in calculation of the risk for SPLC as well as handling of risky patients for a better survival.
Methods:
This is a retrospective study for a period of 5 years where all the data that was gathered from clinical cartels of patients with lung cancer were analyzed using Pearson Chi-Square.
Results:
SPLC represents 2% of all lung cancers diagnosed during the period of study. The prior diagnose of cancer for this patients was breast cancer in 46% of cases, cervix cancer in 40% of cases and the other diagnosis 14% of cases. All the patients have been under oncologic treatment with radio or chemotherapy. 20% of these patients have been smokers prior to first malignancy. The average age of the patients with SPLC was 55 years old. The ratio male to female was 1:10. The most frequent hystotipe found was adenocarcinoma in 60% of cases meanwhile in all cases with a prior squamous cell cancer of cervix was found squamous cell carcinoma as SPLC. The average period of time from the prime cancer to the SPLC was 3.7 years. 73% of cases with SPLC underwent an anatomical resection of the tumor.
Conclusion:
This study shows that patients with the higher risk for a SPLC are premenopausal women with breast cancer and cervical cancer. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks. The relative risk of developing SPLC in smokers is unclear. SPLC after oncologic treatment is an issue that raises many questions.
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P2.04 - Poster Session with Presenters Present (ID 466)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Mesothelioma/Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
- Presentations: 2
- Moderators:
- Coordinates: 12/06/2016, 14:30 - 15:45, Hall B (Poster Area)
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P2.04-044 - Mediastinal Neurogenic Tumors: Histopathological Characteristics and Surgical Treatment in a Single-Institutional Experience (ID 4169)
14:30 - 14:30 | Author(s): Z. Pupla
- Abstract
Background:
Intrathoracic neurogenic tumors are uncommon and typically originate from the peripheral nerves, paraganglionic nerves, or the autonomic nervous system. They are commonly found in the mediastinum, especially in the posterior mediastinum and have a variety of clinical and histological features. Mediastinal neurogenic tumors in adults are generally benign lesions.
Methods:
We retrospectively reviewed our institutional experience of mediastinal neurogenic tumors from 2010 to 2015. The patients were evaluated according to age, gender and histological characteristics of the tumor.
Results:
There were 78% males and 22% females diagnosed with mediastinal neurogenic tumors. Mean age was 48.4±12 years. Distribution according to the histopathological diagnosis was: 56% schwannoma, 22% malignant schwannoma, 22% ganglioneuroma. The operative procedure performed in all cases was tumor extirpation through thoracotomy. In 10% of cases, presence of intraspinal growth was encountered (the so-called "dumbbell tumors"), thus hemilaminectomy was performed. There were no operative deaths and minimal morbidity. Mean postoperative stay was 5 days.
Conclusion:
In this study, the most common mediastinal neurogenic tumor found was schwannoma. Neurogenic tumors arising in the mediastinum are generally of benign nature and mostly found in males. The treatment of choice for malignant and benign mediastinal neurogenic tumors is complete resection for the purposes of avoiding local invasion, facilitating differential histopathological diagnosis and preventing malignant degeneration. The surgical management of the dumbbell tumors differs from others.
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P2.04-045 - Management of Malignant Pleural Effusions: Ten Years Experience of a Single Center (ID 4631)
14:30 - 14:30 | Author(s): Z. Pupla
- Abstract
Background:
Malignant pleural effusions (MPE) are a common clinical problem for patients with neoplastic disease. MPE may be an accompanying sign of them and sometimes the first sign. This study is an overview of diagnosis and treatment of MPE and its aim is to assess the role of invasive procedures in management of such patients.
Methods:
This is a retrospective study for a period of ten years where have been examined all clinical cartels of patients with pleural effusions. All date are analyzed with Pearson Chi-Square test.
Results:
This study has demonstrated that MPE represent 10 % of all pleural effusions. 46% of them have been smokers. 53% of MPE was in the right hemithorax, 38% in the left hemithorax and only 9% was bilateral. The age range was (18-91), and the average age was 63 years old. 37% of these patients have had recent surgery for neoplasia, and in 27% there is no information for recent malignancy and pleural fluid was the first sign of patients. 14% of these patients have relatives with neoplasia. 48% of the cases underwent to biopsy via Video Assisted Thoracic Surgery (VATS) meanwhile for the others the diagnosis was decided by fibrobronchoscopy. In 90% of cases the definitive surgical treatment was pleural drainage and chemical pleurodesis(sol betadine 20 ml + sol NaCl 0,9% 80 ml), in 5% of cases the patient underwent to partial pleurectomy and in 5% of cases wasn’t performed any surgical procedure. Hospitalization day average was 9 days. Performance status was: in 60.2% of cases improved, in 37.2% of cases the same and 2.3% of cases died in hospital. Positive result of pleural biopsy was in 97% of cases. The main hystotype was Adenocarcinoma of lung in men (35% of cases) and Ductal carcinoma of breast (18% of cases) followed by Adenocarcinoma of lung (10% of cases) in women. Mesotelioma was found in 7% of cases.
Conclusion:
Pleural fluid analysis and cytology should continue to be a first-line investigation to screen out the suspiciously MPE cases, as it is a very convenient, cost-effective and safe investigation. Its combination with pleural biopsy through VATS represents the key of success in diagnosing pleural malignant lesions. The most appropriate surgical treatment for MPE seems to be pleural drainage and chemical pleurodesis because of their origin mostly extrapleural malignancy.
