Author of

• 16637

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  P1.03 - Poster Session with Presenters Present (ID 455)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Radiology/Staging/Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16718

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    P1.03-081 - Synchronous Triple Malignant Tumors of the Lung: A Case Report of Two Lung Adenocarcinomas, and Mucosa-Associated Lymphoid Tissue Lymphoma (ID 5775)

    14:30 - 14:30  |  Author(s): H. Zhao
    • Abstract

    Background:
    Synchronous primary malignant tumors are relatively rare. The accurate diagnosis remains challenging.
    
    Methods:
    We report a case of synchronous triple primary tumors of the right lung in a 64-year-old male patient in whom each tumor presented distinct CT imaging findings. Abnormal nodules were found in the lung（one in right upper lobe and another in the right lower lobe）. Almost 2 years later, Chest CT revealed that the nodule in the right lower lobe had grown. After complete resection, pathological sections revealed the similar pathological features of two adenocarcinomas. As the L858R mutation within exon 21 of the EGFR gene was identified in the lower lobe tumor but not in the upper-lobe tumor, we diagnosed as double primary lung adenocarcinomas. We performed the right lower lobe tumor. Pathological examination revealed a combined adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Figure 1
    
    
    
    Results:
    This is the first case of triple malignant tumors (two lung adenocarcinomas, and MALT lymphoma) reported in the literature.
    
    Conclusion:
    Because of its rarity, MALT lymphoma should be considered in the differential diagnosis when we encounter abnormal nodules in patients with synchronous malignant tumors of the Lung.Mutational analysis of the EGFR gene provided important information not only in decision-making of selection of chemotherapeutic agent but also in the diagnosis of double primary cancers.