Author of

• 16637

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  P1.03 - Poster Session with Presenters Present (ID 455)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Radiology/Staging/Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16708

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    P1.03-071 - Impact of Visceral Plural Invasion to T Descriptors: Based on the Forthcoming Eighth Edition of TNM Classification for Lung Cancer (ID 5702)

    14:30 - 14:30  |  Author(s): T. Matsunaga
    • Abstract

    Background:
    According to the forthcoming eighth edition of TNM classification, T descriptors and M descriptors will be subdivided. Visceral plural invasion of lung cancer has been known as a non-size-based T2 descriptor. However, the definition still lacks in detail, and its validation is not included.
    
    Methods:
    We retrospectively reviewed 1250 patients, who underwent curative surgical resection for non-small cell lung cancer at Juntendo University Hospital, between January 2008 and December 2014. Patients with pathologic N1 or N2 disease were excluded. We subdivided tumor size based on the eighth edition of TNM classification. Cumulative survival rates were evaluated by the Kaplan–Meier method. Statistical differences in survival status were evaluated using the log-rank test.
    
    Results:
    In tumor size of 0-4cm, overall survival was significantly different between pl0 and pl1-pl2 in each tumor size; 0-1cm (p<0.0001), 1-2cm (p=0.001), 2-3cm (p=0.007), 3-4cm (p=0.012). In tumor size of over 4cm, overall survival was not different between pl0 and pl1-pl2 in each tumor size; 4-5cm (p=0.825), 5-7cm (p=0.311), over 7cm (p=0.272). In tumor size of 4-5cm with pl0-pl2, a five-year survival rate was 60%. In tumor size of 0-4cm with pl0-pl1, a five-year survival rate was not significant difference with in tumor size of 4-5cm with pl0-pl2; 0-1cm 50% (p=0.799), 1-2cm 71% (p=0.169), 2-3cm 70% (p=0.370), 3-4cm 67% (p=0.609).
    
    Conclusion:
    In pathologic N0M0 disease, there was no prognostic difference between tumor size of 0-4cm with pl1-pl2 and 4-5cm with any pl. In this study, tumors 4cm or less with visceral plural invasion become classified as T2b, and tumors larger than 4cm but 5cm or less also become classified as T2b regardless of visceral plural invasion.