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N.S. Lam
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P1.02 - Poster Session with Presenters Present (ID 454)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.02-001 - Expressions of Resistance EGFR TKIs in Non Small Cell Lung CancerAt Pham Ngoc Thach Hospital - Viet Nam (ID 3747)
14:30 - 14:30 | Author(s): N.S. Lam
- Abstract
Background:
In the patients with NSCLC were tested for diagnostic EGFR mutation, in addition to activating mutations, such as Exon 19 Deletion & Exon 21 L858R that is occupies a large amount. The mutation is said to be resistant to EGFR TKIs occupies smaller amount. However, this is also a challenge for the care and treatment for patients with NSCLC.
Methods:
Retrospective, cross-sectional descriptive statistics, clinical case series.
Results:
PRIMARY MUTATIONS WITH EGFR TKIs RESISTANCE §Activating EGFR Mutations: Exon 19 Deletion: 356/597 cases = 59,63% and Exon 21 L858R: 176/597 cases = 29,48%. §Primary Mutations with EGFR TKIs Resistance - Single mutations: 46/597 cases = 7,71% (Male: 27 cases + Female: 19 cases), including: Exon 20 Insertion: 25 cases, Exon 18 G719X: 14 cases, Exon 20 S768i: 5 cases, Exon 20 T790M: 2 cases. §Primary Mutations with EGFR TKIs Resistance - Double mutations: 19 / 597 cases = 3,18% (Male: 11 cases + Female: 8 cases), including: Exon 21 L858R + Exon 20 T790M: 6 cases, Exon 19 Deletion + Exon 20 T790M: 5 cases, Exon 18 G719X + Exon 20 Insertion: 2 cases, Exon 21 L858R + Exon 20 G786i: 3 cases, Exon 18 G719X + Exon 20 S768i: 3 cases. ACQUIRED MUTATIONS WITH EGFR TKIs RESISTANCE §Total cases with the gene mutation diagnosis repeating again (Sampling with Histology or Cytology): 113/597 cases (18,93%). Detection rate for new resistance EGFR TKIs mutations: Number of Cases: 56 cases/113 cases (49,56%). §Distribution rate % of acquired resistance mutations in EGFR TKIs: · Exon 20 T790M (Single & Double Mutations): 28 cases (50 %) · MET Amplification: 4 cases (7,14 %) · HER2 Amplification: 13 cases (23,21 %) · Small Cell Carcinoma Transformation: 5 cases (8,93 %) · PIK3CA Mutation: 2 cases (3,58 %) · The Other Mutations: 4 cases (7,14 %) §The expression of EGFR T790M mutation: T790M Single Mutation: 14 cases; T790M + Exon 20 Insertion: 3 cases; T790M + A763V: 4 cases; T790M + L777G: 1 case; T790M + Y801C: 3 cases; T790M + G719X: 2 cases; T790M + S768i: 1 case.
Conclusion:
§ There are the expressed resistance mutations EGFR TKIs in NSCLC patients at Pham Ngoc Thach Hospital, including: Primary EGFR TKIs Resistance & Acquired EGFR TKIs Resistance. § The rate of drug-resistant mutant EGFR TKIs are small but still important issues in the Care and Treatment of lung cancer.
